ArticleHealth science reports2026
Association Between Estimated Glucose Disposal Rate and Biological Aging Among U.S. Adults: A Cross-Sectional Study.
Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Background and Aims: Biomarkers of biological aging, including homeostatic dysregulation (HD), Klemera-Doubal method biological age (KDM-BA), and phenotypic age (PA), provide multidimensional quantification of the aging process. Although insulin resistance correlates with accelerated aging, the connection between biological aging and the estimated glucose disposal rate (eGDR)-a proxy indicator of insulin sensitivity-has yet to be systematically examined. Methods: This cross-sectional study analyzed 15,048 U.S. adults from the National Health and Nutrition Examination Survey (NHANES, 2003-2018). eGDR was calculated as: 21.158 - (0.09 × waist circumference) - (3.407 × hypertension) - (0.551 × HbA1c). To evaluate relationships between eGDR and markers of biological aging, weighted multivariable linear and logistic regression models were employed, supplemented by trend analyses. Restricted cubic splines (RCS) modeled nonlinear relationships. Subgroup analyses evaluated effect modifications by demographic/clinical factors. Results: Following comprehensive adjustment, a 1-unit elevation in eGDR demonstrated significant correlations with a 1.88-year decline in KDM-BA ( Conclusion: In this large cross-sectional analysis of US adults, higher eGDR levels were associated with younger biological age and lower odds of accelerated aging. Higher eGDR levels were associated with younger biological age and reduced risks of accelerated aging.
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