ReviewInternational journal of nanomedicine2026
Nature-Inspired Alternatives to PEG for Next-Generation Long-Circulating Nanocarriers.
Review in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyethylene glycol (PEG) has long been considered as the gold standard for imparting stealth properties to nanocarriers. However, the recent emergence of anti-PEG antibodies has spurred innovation toward nature-inspired alternatives. By mimicking the structural and functional architectures of biological systems such as cell membranes and protein corona, nanocarriers can be engineered to achieve prolonged circulation, superior biocompatibility, and active targeting capabilities. This perspective presents nature-inspired alternatives to PEG, including cell membranes and the protein corona, for extending the circulation time of nanocarriers. It also highlights current challenges associated with these nature-inspired alternatives and outlines future research directions to overcome these hurdles in designing next-generation long-circulating nanocarriers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.