ArticleJournal of inflammation research2026
Unfractionated Heparin Attenuates Histone-Induced Pulmonary Endothelial Glycocalyx Injury: A Preliminary Study on the Roles of the ROCK Pathway and Heparanase‑1.
Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This study aims to investigate the role of the Rho-associated kinase (ROCK)-1 pathway, with the involvement of heparanase (HPA)-1, in histone-induced disruption of the endothelial glycocalyx and the protective effects of unfractionated heparin (UFH). Methods: Human pulmonary microvascular endothelial cells (HPMECs) were cultured in vitro and divided into 4 groups: control group, histone group, histone+UFH group, and histone+ROCK inhibitor (Y27632) group. The control group was treated with phosphate buffer solution (PBS). Histone group was treated with histone 50μg/mL for 1 hour. UFH 10 IU/mL and Y27632 10 uM were added 30 min before exposure to histones. Results: UFH attenuated histone-induced permeability changes of HPMECs. UFH reduced histone-induced syndecan-1 shedding and the depolymerization of Ace-tubulin and β-tubulin. UFH inhibited histone-induced decrease in syndecan-1 and Ace-tubulin. UFH inhibited histone-induced expression, re-distribution and secretion of HPA-1. UFH reduced histone-induced expression of ROCK-1 and phosphorylated myosin light-chain (p-MLC) in HPMECs. Conclusion: UFH protects the glycocalyx and endothelial barrier while inhibiting histone induced HPA expression, perinuclear distribution, and secretion, with the involvement of the ROCK pathway.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.