ArticleFrontiers in medicine2026
Desflurane combined with ciprofol or esketamine improves postoperative symptoms without compromising early neurocognitive recovery after intracranial aneurysm endovascular coiling.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This randomized controlled trial aimed to compare the effects of three anesthetic regimens-desflurane + 0.9% saline (DS), desflurane + ciprofol (DC), and desflurane + esketamine (DE)-on early postoperative neurocognitive recovery and perioperative adverse events in patients undergoing endovascular coiling for intracranial aneurysms. Methods: This randomized controlled trial enrolled 210 patients scheduled for urgent endovascular coiling of intracranial aneurysms. Patients were randomly assigned in a 1:1:1 ratio to receive DS, DC, or DE. Neurocognitive function was evaluated using the Montreal Cognitive Assessment (MoCA) before surgery, on postoperative day 1 (POD 1), and on postoperative day 5 (POD 5). Secondary outcomes included the incidence of postoperative nausea and vomiting (PONV), dizziness, numerical rating scale (NRS) pain scores, and the requirement for rescue antiemetic medication. This study was registered at the Chinese Clinical Trial Registry (ChiCTR2500097866). Results: The MoCA scores improved significantly over time across all groups ( Conclusion: In patients undergoing endovascular coiling for intracranial aneurysms, desflurane-based anesthesia supplemented with ciprofol or esketamine does not compromise early neurocognitive recovery. Desflurane plus ciprofol effectively reduces PONV and dizziness, whereas desflurane plus esketamine provides superior analgesia. These findings support personalized, symptom-targeted anesthetic strategies to enhance perioperative safety and recovery.
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