ReviewFrontiers in immunology2026
Boron neutron capture therapy combined with immunotherapy: insights from radiotherapy, BNCT-specific evidence, and future directions.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Boron neutron capture therapy (BNCT), a precision radiotherapy modality, has shown significant promise in targeted cancer treatment. Like conventional radiotherapy, the development of radioresistance hinders the efficacy of BNCT. Nevertheless, the physical parameters in BNCT induce the massive anti-tumor response compared to low-LET radiotherapy. Recent advancements have highlighted its synergistic potential with immunotherapy. In this review, we explore how the unique physical-to-biological trajectory of BNCT drives a potent "Cold-to-Hot" transformation of the tumor microenvironment. We describe how radiotherapy remodels the tumor microenvironment and extrapolate the potential mechanism by which BNCT influences anti-tumor response based on the principles of conventional radiotherapy. BNCT-induced immunogenic cell death and neoantigen presentation activate dendritic cells and CD8
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