Direct exposure to vinclozolin induces sex-dependent mitochondrial dysfunction in mouse liver.

Hwayeon Lim, Jisun Choi, Joo Young Huh, Hoonsung Cho, Sooim Shin

Abstract read

In one paragraph

Article in Current research in toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hwayeon LimDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA.

Jisun ChoiDepartment of Biomaterials Convergence, Chonnam National University, Gwangju 61186, South Korea.

Joo Young HuhCollege of Pharmacy, Chung-Ang University, Seoul 06974, South Korea.

Hoonsung ChoDepartment of Materials Science & Engineering, Chonnam National University, Gwangju 61186, South Korea.

Sooim ShinDepartment of Biotechnology and Bioengineering, Chonnam National University, Gwangju 61186, South Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vinclozolin is a dicarboximide anti-androgenic fungicide that has endocrine-disrupting impact on mammals. Endocrine disruptors are reported to impair mitochondrial function and reduce adenosine triphosphate (ATP) production. Moreover, increasing evidence has linked exposure to endocrine disruptors with metabolic diseases. However, the toxicity of direct exposure to vinclozolin on mitochondrial function remains insufficiently explored. In this study, mitochondria were isolated from mouse liver-one of the primary organs involved in the uptake and processing of toxicants-and directly exposed to vinclozolin. Several markers, including citrate synthase, mitochondrial complex IV (CIV) activity, ATP production, reactive oxygen species/reactive nitrogen species (ROS/RNS) levels, cytochrome

Indexed as

Endocrine disruptorFungicideMitochondriaMitochondrial dysfunctionOxidative stressVinclozolin

Identifiers

PMID42292736

DOI10.1016/j.crtox.2026.100302

PMCPMC13254974

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.