Evidence map›Paper›PMID 42292845›Full record

ArticleFrontiers in pharmacology2026

Dicaffeoylquinic acid alleviates alcoholic liver disease by targeting PLA2G4B and inhibiting the MAPK signaling pathway.

Linlin Wang, Hailong Wang, Yu Miao, Hamulati Hasimu, Tengfei Ji, Hua Huang, Guanhua Du, Haji Akber Aisa, Xuelei Xin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Linlin WangState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, and the Key Laboratory of Chemistry of Plant Resources in Arid Regions Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China.
Hailong WangXinjiang Medical University, Urumqi, China.
Yu MiaoState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, and the Key Laboratory of Chemistry of Plant Resources in Arid Regions Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China.
Hamulati HasimuXinjiang Key Laboratory of Uygur Medicine, Xinjiang Institute of Materia Medica, Urumqi, China.
Tengfei JiState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College and Beijing Key Laboratory of Drug Target and Screening Research, Beijing, China.
Hua HuangXinjiang Key Laboratory of Uygur Medicine, Xinjiang Institute of Materia Medica, Urumqi, China.
Guanhua DuState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College and Beijing Key Laboratory of Drug Target and Screening Research, Beijing, China.
Haji Akber AisaState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, and the Key Laboratory of Chemistry of Plant Resources in Arid Regions Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China.
Xuelei XinState Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, and the Key Laboratory of Chemistry of Plant Resources in Arid Regions Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Alcoholic liver disease (ALD) is a serious global health burden with limited effective therapies. 4,5-Dicaffeoylquinic acid (DCA-C), a monomer from Artemisia scoparia, exhibits multiple bioactivities, but its protective effects and exact mechanisms against ALD remain unclear. Methods: Ethanol-induced ALD mouse models were treated with DCA-C at 10, 30, and 100 mg/kg. Liver injury, lipid accumulation, and inflammation were evaluated. Transcriptomic sequencing and molecular docking were used to identify key targets. PLA2G4B overexpression models in vitro and in vivo were constructed to validate the mechanism. Results: DCA-C dose-dependently alleviated alcoholic liver injury, with the 100 mg/kg dose being most effective, as shown by reduced serum ALT/AST, decreased hepatic triglycerides, and suppressed pro-inflammatory cytokines. PLA2G4B was identified as a core target of DCA-C. DCA-C directly bound PLA2G4B, downregulated its expression, and reduced arachidonic acid (AA) release, thereby inhibiting MAPK signaling (ERK, p38, JNK phosphorylation). PLA2G4B overexpression abolished the protective effects of DCA-C Discussion: DCA-C protects against ALD via targeting PLA2G4B and inhibiting the AA-MAPK pathway. DCA-C is a promising candidate for ALD treatment and warrants further development.

Indexed as

4,5-dicaffeoylquinic acidalcoholic liver diseaseArtemisia scopariaMAPK signaling pathwayPLA2G4B

Identifiers

PMID42292845
PMCPMC13259897

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.