ReviewFrontiers in aging neuroscience2026
Mitochondrial dysfunction in Alzheimer's disease: connecting pathophysiology with neuroimaging.
Review in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Alzheimer's disease (AD), primarily characterized by progressive cognitive decline, poses a significant global public health challenge. Emerging evidence indicates that mitochondrial dysfunction plays a central role in AD-related neurodegeneration. This dysfunction manifests as impaired energy metabolism and elevated oxidative stress, and it interacts with β-amyloid (Aβ) and phosphorylated tau (p-tau) pathologies, collectively forming a self-reinforcing vicious cycle. This review systematically explores the mechanisms underlying mitochondrial dysfunction in AD and highlights recent advancements in neuroimaging technologies, such as positron emission tomography (PET), magnetic resonance spectroscopy (MRS), and susceptibility-weighted imaging (SWI), for detecting mitochondrial abnormalities and metabolic disturbances. These multimodal imaging modalities enable the
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