Evidence map›Paper›PMID 42293319›Full record

ArticleBrain communications2026

Dose-dependent white matter changes associated with repetitive head impacts in former American football players.

Hector Arciniega, Alana Wickham, Brian Szekely, Nicholas Kim, Kang I Cho, Holly Carrington, Evdokiya E Knyazhanskaya, Omar John, Leonard B Jung, Katherine Breedlove and 24 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Hector ArciniegaDepartment of Rehabilitation Medicine, NYU Grossman School of Medicine, NewYork, NY 10016, USA.ORCID https://orcid.org/0000-0002-5565-9633
Alana WickhamDepartment of Rehabilitation Medicine, NYU Grossman School of Medicine, NewYork, NY 10016, USA.
Brian SzekelyDepartment of Rehabilitation Medicine, NYU Grossman School of Medicine, NewYork, NY 10016, USA.
Nicholas KimPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02145, USA.
Kang I ChoPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02145, USA.
Holly CarringtonPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02145, USA.
Evdokiya E KnyazhanskayaPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02145, USA.
Omar JohnDepartment of Rehabilitation Medicine, NYU Grossman School of Medicine, NewYork, NY 10016, USA.
Leonard B JungPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02145, USA.ORCID https://orcid.org/0009-0004-2125-5923
Katherine BreedloveCenter for Clinical Spectroscopy, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID https://orcid.org/0000-0003-4408-3728
Anya S MirmajlesiDepartment of Rehabilitation Medicine, NYU Grossman School of Medicine, NewYork, NY 10016, USA.
Jared StearnsDepartment of Rehabilitation Medicine, NYU Grossman School of Medicine, NewYork, NY 10016, USA.ORCID https://orcid.org/0009-0002-5326-2090
Richard Jarrett RushmorePsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02145, USA.
Daniel H DaneshvarDepartment of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, MA 02115, USA.
Tim L T WiegandPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02145, USA.
Tashrif BillahPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02145, USA.
Ofer PasternakPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02145, USA.
Suheyla Cetin-KarayumakPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02145, USA.
Yogesh RathiPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02145, USA.
Michael J ColemanPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02145, USA.
Charles H AdlerDepartment of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA.ORCID https://orcid.org/0000-0002-1045-2743
Charles BernickCleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, NV 89106, USA.
Laura J BalcerDepartment of Neurology, NYU Grossman School of Medicine, NewYork, NY 10016, USA.
Brian S ImDepartment of Rehabilitation Medicine, NYU Grossman School of Medicine, NewYork, NY 10016, USA.
Shae DattaNYU Langone Concussion Center, NYU Langone Health, NewYork, NY 10016, USA.
Michael L AloscoDepartment of Neurology, Boston University Alzheimer's Disease Research Center and CTE Center, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.ORCID https://orcid.org/0000-0002-8113-8428
Inga K KoertePsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02145, USA.ORCID https://orcid.org/0000-0003-1281-9286
Alexander P LinCenter for Clinical Spectroscopy, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Jeffrey L CummingsChambers-Grundy Center for Transformative Neuroscience, Department of Brain Health, Kirk Kerkorian School of Medicine, University of Nevada, Las Vegas, Las Vegas, NV 89154, USA.
Eric M ReimanBanner Alzheimer's Institute, Arizona State University, and Arizona Alzheimer's Consortium, Phoenix, AZ 85006, USA.
Robert A SternDepartment of Anatomy and Neurobiology, Chobanian and Avedisian School of Medicine, Boston University, Boston, MA 02118, USA.
Martha E ShentonPsychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02145, USA.
Sylvain BouixDepartment of Software Engineering and Information Technology, École de technologie supérieure, Université du Québec, Montréal, QC, Canada H3C 1K3.
DIAGNOSE CTE Research Project

Funding

Research Education ComponentP30AG066512 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Mary Sherman Mittelman · 2020 to 2026
$28.4M
Understanding the Neuroanatomical Abnormalities of Repetitive Head ImpactsR21NS140565 · NINDS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Hector Arciniega · 2025 to 2026
$466k
NIA NIH HHS P30 AG066512NIMHD NIH HHS L32 MD016519NINDS NIH HHS R21 NS140565
6 · The paper itself

Abstract

Repetitive head impacts sustained during American football have been associated with neuropathological changes such as white matter shear injuries. However, the impact of specific factors, such as age of first exposure and cumulative head impact burden, on white matter integrity remains unclear. This study investigated

Indexed as

American footballdiffusion tensor imagingneuroimagingrepetitive head impactsports-related head injury

Identifiers

PMID42293319
PMCPMC13253572

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.