Evidence map›Paper›PMID 42293381›Full record

ArticleMaterials today. Bio2026

Enhanced functional mitochondrial donation through glucose-responsive antioxidant microcarrier-engineered native-like MSCs accelerates diabetic wound healing.

Xiaoxue Yang, Lin Ma, Anqi Liu, Peisheng Liu, Xinyue Cai, Siyuan Fan, Hao Guo, Kun Xuan, Xiaoyao Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaoxue YangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Disease, Department of Preventive Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, Shanxi, 710032, China.
Lin MaState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Disease, Department of Preventive Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, Shanxi, 710032, China.
Anqi LiuState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Disease, Department of Preventive Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, Shanxi, 710032, China.
Peisheng LiuState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Disease, Department of Preventive Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, Shanxi, 710032, China.
Xinyue CaiState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Disease, Department of Preventive Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, Shanxi, 710032, China.
Siyuan FanState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Disease, Department of Preventive Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, Shanxi, 710032, China.
Hao GuoState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Disease, Department of Preventive Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, Shanxi, 710032, China.
Kun XuanState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Disease, Department of Preventive Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, Shanxi, 710032, China.
Xiaoyao HuangState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Disease, Department of Preventive Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, Shanxi, 710032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes impairs wound healing due to hyperglycemia-induced vascular dysfunction. This condition triggers mitochondrial impairment, leading to ferroptosis in endothelial cells. While mesenchymal stromal cells (MSCs) can promote tissue repair through intercellular mitochondrial transfer, strategies to enhance their mitochondrial-donating capacity under hyperglycemic conditions remain underdeveloped. Mesenchymal condensation endows MSCs with enhanced regenerative potential and greater mitochondrial functionality. Microcarrier-based three-dimensional (3D) dynamic culture systems mimicking this process offer a promising strategy. However, effectively shielding donor MSCs from hyperglycemia-induced oxidative stress remains a key challenge in microcarrier design. Here, we engineered a glucose-responsive antioxidant biomaterial-based 3D dynamic culture system using chitosan-formylphenylboronic acid (CS-FPBA) microcarriers combined with stem cells from human exfoliated deciduous teeth (SHED) to generate native-like SHED (N-SHED). This system provides a protective niche for transplanted SHED through glucose-triggered antioxidant microcarrier degradation while simultaneously enhancing mitochondrial function and intercellular transfer. Consequently, N-SHED attenuated endothelial ferroptosis, promoted angiogenesis, and accelerated diabetic wound healing in vivo. This study presents a native-like cell culture platform that amplifies the therapeutic efficacy of MSCs by enhancing their mitochondrial-donating capacity. With strong translational potential, this strategy not only advances MSCs-based therapy for diabetic wounds but also offers a novel framework for mitochondrial-targeted regenerative medicine.

Indexed as

Diabetic wound healingFerroptosisGlucose-responsive microcarrierMitochondrial transferStem cells from human exfoliated deciduous teethThree-dimensional dynamic culture system

Identifiers

PMID42293381
PMCPMC13253141

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.