ArticleInfection and drug resistance2026
Identification of ROS-Related Gene TNFSF13B as a Diagnostic Biomarker in Tuberculosis: Insights from WGCNA.
Article in Infection and drug resistance, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Despite medical advances, active tuberculosis (TB) remains difficult to diagnose, particularly in asymptomatic or paucibacillary cases lacking detectable pathogen evidence. Elevated oxidative stress is a hallmark of Methods: Microarray data were derived from 10 healthy donors (HCs) and 10 active TB patients recruited from Beijing Chest Hospital. Other external datasets for validation were obtained from the Gene Expression Omnibus database. Correlation analysis of gene expression and immune cell infiltration using the CIBERSORT approach. WGCNA was employed to identify the critical modules associated with immune cells. Results: WGCNA and immune infiltration analysis identified a monocyte-associated module harboring five ROS-related genes. Among these, Conclusion: Our findings identify TNFSF13B as a macrophage-specific, oxidative stress-related biomarker with strong potential for active TB diagnosis, not only for differential diagnosis from other pulmonary diseases but also for monitoring TB treatment response.
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