Evidence map›Paper›PMID 42294094›Full record

ArticleTransplant international : official journal of the European Society for Organ Transplantation2026

Transplantation of older DCD livers in the machine perfusion era: a U.S. cohort study.

Emmanouil Giorgakis, Ioannis A Ziogas, Dimitrios Moris, Dimitrios N Varvoglis, Charalampos Theocharopoulos, Dor Yoeli, Megan A Adams, Andrew S Barbas, Martin I Montenovo, Melissa Chen and 13 more

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In one paragraph

Article in Transplant international : official journal of the European Society for Organ Transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Emmanouil GiorgakisDivision of Abdominal Transplantation, Department of Surgery, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, United States.
Ioannis A ZiogasDivision of Transplant Surgery, Department of Surgery, University of Colorado Anschutz Medical Campus, Children's Hospital Colorado, Aurora, CO, United States.
Dimitrios MorisDepartment of Surgery, MedStar Georgetown Transplant Institute, Washington, DC, United States.
Dimitrios N VarvoglisDivision of Transplant Surgery, Department of Surgery, University of Colorado Anschutz Medical Campus, Children's Hospital Colorado, Aurora, CO, United States.
Charalampos TheocharopoulosDivision of Transplant Surgery, Department of Surgery, University of Colorado Anschutz Medical Campus, Children's Hospital Colorado, Aurora, CO, United States.
Dor YoeliDivision of Transplant Surgery, Department of Surgery, University of Colorado Anschutz Medical Campus, Children's Hospital Colorado, Aurora, CO, United States.
Megan A AdamsDivision of Transplant Surgery, Department of Surgery, University of Colorado Anschutz Medical Campus, Children's Hospital Colorado, Aurora, CO, United States.
Andrew S BarbasDivision of Abdominal Transplant Surgery, Department of Surgery, Duke University Medical Center, Durham, NC, United States.
Martin I MontenovoDivision of Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, United States.
Melissa ChenDivision of Transplant Surgery, Mayo Clinic, Phoenix, Arizona, NC, United States.
Sorabh KapoorDivision of Transplant Surgery, Mayo Clinic, Phoenix, Arizona, NC, United States.
Esteban CalderonDivision of Transplant Surgery, Mayo Clinic, Phoenix, Arizona, NC, United States.
Andrew M MoonDivision of Transplant Surgery, Mayo Clinic, Phoenix, Arizona, NC, United States.
Sasha Deutch-LinkDivision of Transplant Surgery, Mayo Clinic, Phoenix, Arizona, NC, United States.
Hersh ShroffDivision of Transplant Surgery, Mayo Clinic, Phoenix, Arizona, NC, United States.
Neil D ShahDivision of Transplant Surgery, Mayo Clinic, Phoenix, Arizona, NC, United States.
Oren K FixDivision of Transplant Surgery, Mayo Clinic, Phoenix, Arizona, NC, United States.
A Sidney BarrittDivision of Transplant Surgery, Mayo Clinic, Phoenix, Arizona, NC, United States.
Amit K MathurDivision of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, United States.
Trevor NydamDivision of Transplant Surgery, Department of Surgery, University of Colorado Anschutz Medical Campus, Children's Hospital Colorado, Aurora, CO, United States.
Chirag S DesaiDivision of Transplant Surgery, Mayo Clinic, Phoenix, Arizona, NC, United States.
Paulo N MartinsTransplant Institute, Department of Surgery, Division of Transplantation, University of Oklahoma, Oklahoma City, OK, United States.
Andrea SchegelTransplant Center, Digestive Disease and Surgery Institute, Cleveland Clinic Foundation, Cleveland, OH, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Donation after circulatory death (DCD) livers increasingly use machine perfusion (MP). This study evaluates MP's impact on older DCD livers based on data from the United Network for Data Sharing, covering all first adult DCD liver transplants (2016-2025). The cohort, divided into pre-MP and MP eras (separated by the FDA approval of the first normothermic MP platform in 2021), showed accelerated growth in DCD liver transplants during the MP era. Donors ≥60 rose 7.8-fold, including donors ≥70 (a USA first). By 2025, DCD livers accounted for 43.2%, with 61.35% from donors ≥50. Normothermic regional perfusion (NRP) (3.0%-16.5%), NMP (2.1%-38.9%), and sequential NRP-NMP (0.1%-10.7%) increased significantly (p < 0.001). The MP era was associated with a decrease in median waitlist time from 112 to 62 days (p < 0.001). Early graft survival was similar across ages. For ages 50-59, 1- and 3-year survivals were 87.9%/78.4% pre-MP and 90.1%/78.8% in the MP era. For 60-69, survival was 85.0%/80.6% pre-MP and 90.0%/71.3% in the MP era. DCD LTs for ≥70 were limited to the MP era with 87.8% 1-year survival. Multivariable Cox regression showed that static cold storage (HR = 1.29), donor age 50-69 versus 18-49, and recipient age (HR = 1.01) increased the risk of graft loss after adjustment. MP is associated with an increased number of older DCD liver transplants and acceptable early graft survival.

Indexed as

Liver TransplantationOrgan PreservationPerfusionAdultAgedCohort StudiesFemaleGraft SurvivalHumansMaleMiddle AgedTissue and Organ ProcurementTissue DonorsUnited StatesWaiting Listsdonation after circulatory deathdynamic preservationhypothermic oxygenated perfusionliver transplantationmachine perfusion

Identifiers

PMID42294094
PMCPMC13260052

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.