Evidence map›Paper›PMID 42294115›Full record

ArticleGynecologic oncology reports2026

Impact of preoperative frailty assessment on peri-operative complications and cancer related outcomes in advanced stage endometrial cancer.

Christine I Cho, Anne-Laure Strong, Brooke Arner, Christina Stetter, Edward Podczaski, Joel I Sorosky, Mark S Shahin, Shaina F Bruce

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gynecologic oncology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Christine I ChoDepartment of Obstetrics and Gynecology at Penn State Health, Hershey Medical Center, Department of Pathology at Penn State Health, Division of Gynecology Oncology at at Penn State Health, Hershey, PA, United States.
Anne-Laure StrongDepartment of Obstetrics and Gynecology at Penn State Health, Hershey Medical Center, Department of Pathology at Penn State Health, Division of Gynecology Oncology at at Penn State Health, Hershey, PA, United States.
Brooke ArnerDepartment of Obstetrics and Gynecology at Penn State Health, Hershey Medical Center, Department of Pathology at Penn State Health, Division of Gynecology Oncology at at Penn State Health, Hershey, PA, United States.
Christina StetterDepartment of Obstetrics and Gynecology at Penn State Health, Hershey Medical Center, Department of Pathology at Penn State Health, Division of Gynecology Oncology at at Penn State Health, Hershey, PA, United States.
Edward PodczaskiDepartment of Obstetrics and Gynecology at Penn State Health, Hershey Medical Center, Department of Pathology at Penn State Health, Division of Gynecology Oncology at at Penn State Health, Hershey, PA, United States.
Joel I SoroskyDepartment of Obstetrics and Gynecology at Penn State Health, Hershey Medical Center, Department of Pathology at Penn State Health, Division of Gynecology Oncology at at Penn State Health, Hershey, PA, United States.
Mark S ShahinDepartment of Obstetrics and Gynecology at Penn State Health, Hershey Medical Center, Department of Pathology at Penn State Health, Division of Gynecology Oncology at at Penn State Health, Hershey, PA, United States.
Shaina F BruceDepartment of Obstetrics and Gynecology at Penn State Health, Hershey Medical Center, Department of Pathology at Penn State Health, Division of Gynecology Oncology at at Penn State Health, Hershey, PA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The impact of pre-operative frailty on outcomes in patients with endometrial cancer is not well studied. The primary aim of this study was to assess the association between preoperative frailty scores and postoperative complications in patients with advanced-stage endometrial cancer. Methods: This is a retrospective cohort study of patients who underwent hysterectomy for advanced-stage endometrial cancer at a single institution. Frailty was defined using the modified frailty index (mFI ≥ 2). Complications were measured with the Comprehensive Complication Index (CCI). Results: A total of 62 were included; 17 met criteria for frail (F) based on mFI. In the non-frail (NF) cohort, 11 patients underwent open surgery vs. 4 in F. There were 34 NF patients in the MIS group, and 13 in F. Complications occurred in 29.4% F vs. 28.9% NF patients, p = 1.00), in the open surgery subgroup (50.0% F vs. 45.5% NF, p = 1.00) and in the minimally invasive surgery subgroup (23.1% F vs. 23.5% NF, p = 1.00). Those with complications had similar median CCI scores (22.6F vs. 24.2 NF, p = 0.84). Median days to adjuvant therapy were similar (39F vs. 43 NF, p = 0.32). Progression free survival (PFS) and overall survival (OS) was similar between groups. Conclusion: Frailty was not associated with increased postoperative complication rate or worse survival in advanced endometrial cancer. Endometrial cancer surgery is largely performed minimally invasively which may be a factor that mitigates the adverse impact of frailty. Our small sample size limits interpretation: larger, multi-institutional studies are needed to determine whether surgical approach offsets the impact of frailty in this population.

Indexed as

Claviendindo classificationEndometrial cancerFrailtyMinimally invasive surgeryModified frailty index

Identifiers

PMID42294115
PMCPMC13253130

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.