Evidence map›Paper›PMID 42294444›Full record

ArticleFrontiers in surgery2026

Predictive value of NRI, NLR, PLR and LMR for therapeutic efficacy and prognosis in advanced rectal cancer patients treated with PD-1/PD-L1 immunotherapy.

Mengli Gao, Zhe Gao, Yanan Wang, Wenguang Song

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mengli GaoDepartment of Oncology, Tangshan Gongren Hospital, Tangshan, Hebei, China.
Zhe GaoDepartment of Oncology, Tangshan Gongren Hospital, Tangshan, Hebei, China.
Yanan WangDepartment of Oncology, Tangshan Gongren Hospital, Tangshan, Hebei, China.
Wenguang SongDepartment of Oncology, Tangshan Gongren Hospital, Tangshan, Hebei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The purpose of the study was to investigate the predictive value of the Nutritional Risk Index (NRI), Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), and Lymphocyte-to-Monocyte Ratio (LMR) for the prognosis and effectiveness of immunotherapy in patients with advanced rectal cancer. Methods: Retrospective analysis of 172 advanced rectal cancer patients undergoing immunotherapy (Feb 2020 - Feb 2023) was performed. The optimal cut-off values of each indicator were determined by receiver operating characteristic (ROC) curves. The Results: The optimal cut-off values of NLR, PLR, LMR, NRI were 2.50, 142.23, 3.92, 50.45. Efficacy analysis revealed that the ORR and DCR in the low NLR, low PLR, high LMR, and high NRI groups were significantly higher than those in the corresponding groups (all Conclusion: These indicators correlate with immunotherapy efficacy/prognosis. Among them, NLR≥2.50 is an independent biomarker for poor efficacy and prognosis, providing references for clinical treatment individualization.

Indexed as

immunotherapyLymphocyte-to-monocyte ratioNeutrophil-to-lymphocyte ratioNutritional risk indexplatelet-to-lymphocyte ratioPredictive Valuerectal cancer

Identifiers

PMID42294444
PMCPMC13253505

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.