Evidence map›Paper›PMID 42294633›Full record

ArticleInfection and immunity2026

Zachary M Powers, Michael J McFadden, Gi Young Lee, Tracey Schultz, Luiza A Castro Jorge, Daniel F Edwards, Simon Sanchez-Paiva, Jonathan Z Sexton, Katherine R Spindler, Jeongmin Song and 1 more

Abstract read
In one paragraph

Article in Infection and immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

  • Update of
    2026
5 · Who and what money

Authors and funding

11 authors.

Zachary M PowersDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.ORCID 0000-0002-3999-4300
Michael J McFaddenDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.ORCID 0000-0003-0303-6968
Gi Young LeeDepartment of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, New York, USA.
Tracey SchultzDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Luiza A Castro JorgeDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.ORCID 0000-0002-1595-3037
Simon Sanchez-PaivaDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Jonathan Z SextonDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Katherine R SpindlerDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.ORCID 0000-0002-9829-6051
Jeongmin SongDepartment of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, New York, USA.ORCID 0000-0002-6777-3505
Mary X O'RiordanDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.ORCID 0000-0001-6014-4637

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eric R. Fearon · 1988 to 2026
$178.2M
Molecular Mechanisms of Microbial Pathogenesis Training ProgramT32AI007528 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CARRUTHERS, VERNON BRUCE · 1998 to 2024
$6.8M
Viral interaction with host eIF2alpha kinasesR01AI133935 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPINDLER, KATHERINE R. · 2018 to 2022
$3.0M
Laser-based high content imaging microscopeS10OD034245 · OD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SEXTON, JONATHAN ZACHARY · 2024 to 2024
$1.4M
Engagement of the macrophage integrated stress response in Salmonella infectionR21AI181115 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI O'RIORDAN, MARY · 2024 to 2025
$407k
Integrated Stress Response-mediated macrophage innate immunity during maladapted Salmonella enterica infectionF31AI186289 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI POWERS, ZACHARY MICHAEL · 2024 to 2025
$88k
Michigan Pioneer Fellows ProgramNCI NIH HHS P30 CA046592NIAID NIH HHS F31 AI186289NIAID NIH HHS R01 AI133935NIAID NIH HHS R21 AI181115NIAID NIH HHS T32 AI007528NIH HHS F31AI186289NIH HHS P30CA046592NIH HHS R01AI133935NIH HHS R21AI181115NIH HHS S10 OD034245NIH HHS S10OD034245NIH HHS T32AI007528University of Michigan Medical School U081355
6 · The paper itself

Abstract

Many intracellular pathogens stimulate host cell stress by directly or indirectly causing an imbalance in host nutrients. Depletion of amino acid pools, in particular, can act as a danger signal to infected cells. Using a restrictive host model of

Indexed as

AsparaginaseMacrophagesProtein Serine-Threonine KinasesSalmonella typhiAnimalsIntegrated Stress ResponseMiceMice, Inbred C57BLSignal TransductionTOR Serine-Threonine KinasesAsparaginaseEif2ak4 protein, mouseProtein Serine-Threonine KinasesTOR Serine-Threonine Kinasesgram-negative bacteriainnate immunitynutritional immunity

Identifiers

PMID42294633
PMCPMC13367068

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.