Observational studyJournal of the American Heart Association2026
Blood Levels of Angiotensinogen and Risk of Ischemic Stroke: The Multi-Ethnic Study of Atherosclerosis.
Observational study in Journal of the American Heart Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
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Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe investigated whether circulating angiotensinogen levels are associated with the risk of ischemic stroke and examined sex-specific differences.
methodsWe included 5622 participants (mean age, 62.7 years; 52% women) free of cardiovascular disease at baseline (2000-2002) and followed them through 2020. Cox models assessed the association between angiotensinogen and ischemic stroke, including sex-stratified hazard ratios (HRs) with 95% CIs. Mediation analyses estimated the contribution of risk factors to observed associations. Subgroup analyses with multiplicative interaction testing were conducted.
resultsDuring follow-up, 283 ischemic stroke events occurred. Each 1-SD increase in log-transformed angiotensinogen was associated with a 16% higher stroke risk (HR, 1.16 [95% CI, 1.00-1.34]). Significant interaction with sex was observed (
conclusionsHigher circulating angiotensinogen levels are associated with an increased risk of ischemic stroke in men, independent of blood pressure.
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