ReviewJournal of virology2026
Role of quaternary epitopes in eliciting broad neutralization response against multiple flaviviruses.
Review in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
2 authors.
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Abstract
Flaviviruses, or orthoflaviviruses, are arthropod-borne RNA viruses that pose a significant global health threat and co-circulate in many regions across the world. Neutralizing antibodies against specific pathogenic flaviviruses, such as dengue virus, Zika virus, and West Nile virus, are well-known. However, vaccine and therapeutic development against many flaviviruses remains challenging due to their antigenic diversity and complex humoral responses. Recent studies have reported patient-derived neutralizing antibodies that are active against multiple flaviviruses. Structural characterization of these pan-flavivirus antibodies has identified quaternary epitopes that are conserved across multiple flaviviruses, emphasizing the importance of quaternary epitopes on native flaviviruses, which, in some cases, are also preserved across different virus morphologies. Understanding the basis of quaternary structural epitope recognition can aid in the design of immunogens that elicit broad protection, with a lower risk of infection enhancement. In this review, we discuss mechanistic insights of bnAbs targeting different quaternary epitopes found on pathogenic flaviviruses, and implications for next-generation pan-flavivirus vaccine strategies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.