ArticleInternational endodontic journal2026
Spatial Transcriptomics Delineates the Inflammatory Landscape of Human Dental Pulp: Regional Crosstalk and Therapeutic Implications.
Article in International endodontic journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimThis study aimed to investigate the spatial cellular architecture and molecular interactions in healthy and inflamed dental pulp using spatial transcriptomics (Visium HD), to elucidate the pathological mechanisms of pulpitis and identify potential therapeutic targets for vital pulp therapy. METHODOLOGY: Spatial transcriptomic sequencing was performed on dental pulp tissues from two healthy individuals and two pulpitis patients, with integrated analyses including Seurat clustering, cell trajectory inference, GO enrichment, CellphoneDB interaction network modelling and PROGENy pathway activity assessment to compare cellular heterogeneity and signalling regulation.
resultsNine major cell types (fibroblasts, progenitor cells, endothelial cells, neural cells, plasma cells, B cells, T cells, monocytes and macrophages) were identified, and their spatial distribution was mapped. Subclustering and differential expression analysis revealed that fibroblast (e.g., APOL2
conclusionsFor the first time, we have identified nine cell populations in dental pulp with their spatial localization and intercellular crosstalk using spatial transcriptomic sequencing technology, and mapped the inflammatory landscape of dental pulp. Cellular remodelling-driven by APP suppression, CXCL14 deficiency and TGFβ activation-is a central mechanism in pulpitis progression. These findings provide a preliminary spatial transcriptomic foundation that may inform the development of targeted strategies for vital pulp therapy.
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