ArticlePharmaceutical biology2026
Zexie decoction alleviates hyperlipidemia through modulation of the PPAR signaling pathway and lysophospholipid metabolism.
Article in Pharmaceutical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
contextZexie Decoction (ZXD) is a classical traditional Chinese medicine prescription that has long been used for the treatment of hyperlipidemia. However, its material basis and underlying mechanisms remain unclear.
objectiveThis research aims to explore the effective compounds and lipid-lowering mechanism of ZXD in the treatment of hyperlipidemia by integrating serum pharmacochemistry, network pharmacology and targeted lipidomics. MATERIALS AND
methodsA high-fat diet-induced hyperlipidemia mouse model was established for evaluating the therapeutic efficacy of ZXD. The absorbed components of ZXD in serum were identified using ultra-high performance liquid chromatography quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS/MS). Network pharmacology analysis based on
resultsPharmacodynamic evaluation demonstrated that ZXD exerted significant lipid-lowering effects on hyperlipidemic mice. Serum pharmacochemistry analysis identified twelve absorbed constituents, including 3 prototype compounds and 9 metabolites. Network pharmacology analysis demonstrated that ZXD primarily modulated lipid metabolism-associated pathways, particularly the peroxisome proliferator-activated receptor (PPAR) signaling pathway and the lipid and atherosclerosis pathways. Molecular docking further revealed strong binding affinities between the major bioactive compounds of ZXD and key targets PPARA and PPARG. In addition, targeted lipidomics identified 36 lysophospholipid biomarkers associated with ZXD-mediated amelioration of hyperlipidemia. DISCUSSION AND
conclusionsIntegrated analysis indicates that ZXD alleviates hyperlipidemia in association with modulation of the PPAR signaling pathway and lysophospholipid metabolism, highlighting a potential lysophospholipid-PPAR regulatory mechanism.
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