Evidence mapPaperPMID 42295671Full record

ReviewSports medicine (Auckland, N.Z.)2026

Toward Precision Cardiac Rehabilitation: Current Limitations and Future Opportunities of Omics and Artificial Intelligence.

Amine Ghram, Javier Loureiro Diaz, Preeti Raghavan, Arto J Hautala, Rasha Kaddoura, Jari A Laukkanen, Setor K Kunutsor, Mohamed A Elrayess, Beat Knechtle, Katja Weiss and 40 more

Abstract readReview
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In one paragraph

Review in Sports medicine (Auckland, N.Z.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

50 authors.

Amine Ghram *Cardiac Rehabilitation Department, Heart Hospital, Hamad Medical Corporation, 3050, Doha, Qatar.ORCID http://orcid.org/0000-0002-2851-0753
Javier Loureiro Diaz *Cardiac Rehabilitation Department, Heart Hospital, Hamad Medical Corporation, 3050, Doha, Qatar.ORCID http://orcid.org/0000-0003-1727-9135
Preeti RaghavanDepartment of Physical Medicine and Rehabilitation and Neurology, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, MD, 21287, USA.ORCID http://orcid.org/0000-0002-7852-5005
Arto J HautalaFaculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland.ORCID http://orcid.org/0000-0002-7648-0130
Rasha KaddouraPharmacy Department, Heart Hospital, Hamad Medical Corporation, 3050, Doha, Qatar.ORCID http://orcid.org/0000-0003-2613-9759
Jari A LaukkanenDepartment of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.ORCID http://orcid.org/0000-0002-3738-1586
Setor K KunutsorSection of Cardiology, Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Saint Boniface Hospital, Winnipeg, MB, R2H 2A6, Canada.ORCID http://orcid.org/0000-0002-2625-0273
Mohamed A ElrayessBiomedical Research Center, QU Health, Qatar University, P.O. Box 2713, Doha, Qatar.ORCID http://orcid.org/0000-0003-3803-4604
Beat KnechtleInstitute of Primary Care, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-2412-9103
Katja WeissInstitute of Primary Care, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0003-1247-6754
Thomas RosemannInstitute of Primary Care, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-6436-6306
Salaheddin M SharifDepartment of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.ORCID http://orcid.org/0000-0002-0570-570X
Amanda R BonikowskeDepartment of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.ORCID http://orcid.org/0000-0001-9317-4330
Thijs M H EijsvogelsExercise Physiology Research Group, Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0003-0747-4471
Linda S PescatelloDepartment of Kinesiology, University of Connecticut, Storrs, CT, USA.ORCID http://orcid.org/0000-0002-5841-798X
Leonard A KaminskyFisher Institute of Health and Well-Being, Ball State University, Muncie, IN, USA.ORCID http://orcid.org/0000-0001-5736-9106
Abraham Samuel BabuDepartment of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, India.ORCID http://orcid.org/0000-0003-1084-0137
Giuseppe Biondi-ZoccaiDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.ORCID http://orcid.org/0000-0001-6103-8510
Manuel Avelino Giráldez-GarcíaPerformance and Health Group, Department of Physical Education and Sport, Faculty of Sports Sciences and Physical Education, University of Coruña, Coruña, Oleiros, Spain.ORCID http://orcid.org/0000-0003-3606-5933
Javaid NaumanHealthy Living for Pandemic Event Protection (HL-Pivot) Network, Chicago, IL, USA.ORCID http://orcid.org/0000-0003-1347-2448
Giuseppe LippiSection of Clinical Biochemistry, University of Verona, Verona, Italy.ORCID http://orcid.org/0000-0001-9523-9054
Josef NiebauerUniversity Institute of Sports Medicine, Prevention and Rehabilitation, Paracelsus Medical University, University Hospital Salzburg, Salzburg, Austria.ORCID http://orcid.org/0000-0002-2811-9041
Francesco PeroneCardiac Rehabilitation Unit, Rehabilitation Clinic "Villa Delle Magnolie", 81020, Castel Morrone, Caserta, Italy.ORCID http://orcid.org/0000-0002-1418-7908
Karim ChamariNaufar Center, Doha, Qatar.ORCID http://orcid.org/0000-0001-9178-7678
Hani SabbourCardiology Department, Mediclinic Airport Road Hospital, Abu Dhabi, United Arab Emirates.ORCID http://orcid.org/0000-0001-6960-1056
Miguel PaniaguaMedical Education, American College of Physicians, Philadelphia, USA.ORCID http://orcid.org/0000-0003-2307-4873
Sara OmarWeill Cornell Medicine, PO Box 24144, Doha, Qatar.ORCID http://orcid.org/0000-0002-1874-015X
Karam I Turk-AdawiDepartment of Public Health, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.ORCID http://orcid.org/0000-0002-4162-7761
Marta SuperviaDepartment of Physical Medicine and Rehabilitation Gregorio Marañón General University Hospital, Gregorio Marañón Health Research Institute, Madrid, Spain.ORCID http://orcid.org/0000-0002-5178-8315
Laila HedayaBiomedical Research Center, QU Health, Qatar University, P.O. Box 2713, Doha, Qatar.ORCID http://orcid.org/0000-0001-5136-9746
Omar IbrahimCardiac Rehabilitation Department, Heart Hospital, Hamad Medical Corporation, 3050, Doha, Qatar.
Mohamed SulimanCardiac Rehabilitation Department, Heart Hospital, Hamad Medical Corporation, 3050, Doha, Qatar.
Praveen Jayaprabha SurendranCardiac Rehabilitation Department, Heart Hospital, Hamad Medical Corporation, 3050, Doha, Qatar.ORCID http://orcid.org/0000-0002-7417-3559
Daniel Martinez-BussionCardiac Rehabilitation Department, Heart Hospital, Hamad Medical Corporation, 3050, Doha, Qatar.ORCID http://orcid.org/0000-0002-5160-0132
Manal S Al ShamariCardiac Rehabilitation Department, Heart Hospital, Hamad Medical Corporation, 3050, Doha, Qatar.
Mohammed AlhashemiCardiac Rehabilitation Department, Heart Hospital, Hamad Medical Corporation, 3050, Doha, Qatar.ORCID http://orcid.org/0000-0003-1480-4707
Tagowg AgabCardiac Rehabilitation Department, Heart Hospital, Hamad Medical Corporation, 3050, Doha, Qatar.
Rehab AhmadCardiac Rehabilitation Department, Heart Hospital, Hamad Medical Corporation, 3050, Doha, Qatar.
M S AjimshaQatar Rehabilitation Institute, Hamad Medical Corporation, 3050, Doha, Qatar.ORCID http://orcid.org/0000-0003-4182-9838
Adam StaronCardiac Rehabilitation Department, The Upper Silesian Medical Center, Katowice, Poland.ORCID http://orcid.org/0000-0001-5489-9160
Adel ShabanaDepartment of Cardiology, Faculty of Medicine, Ain Shams University, 38 Abbassia, Next to the Al-Nour Mosque, Cairo, 1181, Egypt.ORCID http://orcid.org/0000-0001-8874-7341
Amal AlbatiniPhysical Therapy Department, Chest Diseases Hospital, Kuwait City, Kuwait.ORCID http://orcid.org/0000-0003-4271-2391
Abdulfattah S AlqahtaniDepartment of Rehabilitation Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.ORCID http://orcid.org/0000-0002-7396-5079
Raghdah AljehaniCardiopulmonary Rehabilitation Consultant, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia.ORCID http://orcid.org/0000-0003-4143-2830
Aisha AladabDepartment of Pulmonary Medicine, Hamad General Hospital, Hamad Medical Corporation, 3050, Doha, Qatar.ORCID http://orcid.org/0000-0003-2149-7493
Hisham A SattarDepartment of Pulmonary Medicine, Hamad General Hospital, Hamad Medical Corporation, 3050, Doha, Qatar.
Trine Moholdt *Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.ORCID http://orcid.org/0000-0003-1024-8088
Øyvind Sandbakk *School of Sport Science, UiT The Artic University of Norway, Tromsø, Norway.ORCID http://orcid.org/0000-0002-9014-5152
Carl J Lavie *Healthy Living for Pandemic Event Protection (HL-Pivot) Network, Chicago, IL, USA. clavie@ochsner.org.ORCID http://orcid.org/0000-0003-3906-1911
Helmi Ben Saad *Faculty of Medicine of Sousse, Farhat HACHED Hospital, Heart Failure (LR12SP09) Research Laboratory, University of Sousse, Sousse, Tunisia.ORCID http://orcid.org/0000-0002-7477-2965

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular disease involves complex molecular, cellular, and physiological derangements that present challenges for traditional diagnostic and therapeutic approaches. Precision medicine is an evolving field that seeks to tailor interventions according to an individual's genetic, molecular, and physiological characteristics. By leveraging advanced omics approaches, including genomics, proteomics, metabolomics, and microbiomics, precision medicine may enable more comprehensive patient phenotyping and support the development of more individualized strategies. The emerging concept of precision cardiac rehabilitation (CR) could provide a more tailored approach to cardiac care by integrating artificial intelligence (AI) with multimodal data, including clinical, imaging, physiological, and omics information. In this context, AI has been explored as a tool to support risk assessment, exercise prescription, and monitoring during CR. However, current evidence remains limited and heterogeneous. Omics-based approaches are primarily confined to research and translational settings, and their role in guiding individualized exercise prescription or clinical decision making in CR remains unestablished. Similarly, while AI shows promise for improving adherence, remote monitoring, and data integration, its effectiveness for optimizing clinical outcomes in CR requires further validation. Overall, precision CR represents a promising but still evolving paradigm. Future progress will depend on well-designed clinical trials, real-world data integration, standardized methodologies, and interdisciplinary collaboration to determine whether these technologies can be safely and effectively integrated into routine clinical practice.

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.