ArticleChemistry & biodiversity2026
Deciphering Antidiabetic, Anti-Inflammatory, and Anti-Cholinergic Bioactivities of Withania somnifera (L) Dunal Root Extract: An In Vitro and In Silico Investigation.
Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Alzheimer's disease (AD) is a disease associated with loss of brain cholinergic functions and a common cause of dementia. Diabetes and inflammation have been linked to some pathways contributing to AD pathogenesis. In this study, the effects of Withania somnifera (W. somnifera) root ethanol extract (WSEE) on lipoxygenase, butyrylcholinesterase (BChE), protein denaturation, and carbohydrate digestive enzymes were determined using in vitro and in silico experimental models. WSEE cytotoxicity on neuroblastoma cell lines (SH-SY5Y) and the molecular docking simulation of its compounds were also investigated. WSEE analysis showed the presence of terpenoids, flavonoids, alkaloids, and tannins. The extract showed significant (p < 0.05) inhibition of protein denaturation (IC
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