Evidence map›Paper›PMID 42296972›Full record

ArticleDevelopmental cell2026

Genetic interrogation reveals mechanisms regulating nexus glia development and shaping heart physiology.

Sarah E W Light, John Dennen, Anna Barry-Wolbers, Natália Araújo do Carmo, Antonio Dolojan, O Amandhi Mathews, Grace Waddell, Khang Chau, Cara Cavanaugh, Quinn Deitch and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sarah E W LightDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA; The Center for Stem Cells and Regenerative Medicine, University of Notre Dame, Notre Dame, IN 46556, USA.
John DennenDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA; The Center for Stem Cells and Regenerative Medicine, University of Notre Dame, Notre Dame, IN 46556, USA.
Anna Barry-WolbersDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA; The Center for Stem Cells and Regenerative Medicine, University of Notre Dame, Notre Dame, IN 46556, USA.
Natália Araújo do CarmoDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA; The Center for Stem Cells and Regenerative Medicine, University of Notre Dame, Notre Dame, IN 46556, USA.
Antonio DolojanDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA; The Center for Stem Cells and Regenerative Medicine, University of Notre Dame, Notre Dame, IN 46556, USA.
O Amandhi MathewsDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA; The Center for Stem Cells and Regenerative Medicine, University of Notre Dame, Notre Dame, IN 46556, USA.
Grace WaddellDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA; The Center for Stem Cells and Regenerative Medicine, University of Notre Dame, Notre Dame, IN 46556, USA.
Khang ChauDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA; The Center for Stem Cells and Regenerative Medicine, University of Notre Dame, Notre Dame, IN 46556, USA.
Cara CavanaughDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA; The Center for Stem Cells and Regenerative Medicine, University of Notre Dame, Notre Dame, IN 46556, USA.
Quinn DeitchDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA; The Center for Stem Cells and Regenerative Medicine, University of Notre Dame, Notre Dame, IN 46556, USA.
Cody J SmithDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA; The Center for Stem Cells and Regenerative Medicine, University of Notre Dame, Notre Dame, IN 46556, USA. Electronic address: csmith67@nd.edu.

Funding

Investigating the Critical Role of Glia In Peripheral Organ Development and PhysiologyF32HL165966 · UNIVERSITY OF NOTRE DAME · 2025 to 2025
$80k
NHLBI NIH HHS F32 HL165966NINDS NIH HHS DP2 NS117177
6 · The paper itself

Abstract

Functional organs require precise cellular organization to engage in bidirectional communication with the nervous system. However, the cellular specialization underlying this vital communication remains incompletely understood. Here, we investigated zebrafish cardiac nexus glia and found that they are post-mitotic and exhibit dynamic Ca

Indexed as

HeartNeurogliaAnimalsCalciumHumansMyocytes, CardiacZebrafishZebrafish ProteinsCalciumZebrafish Proteinsastrogliacardiac exhaustioncardiac gliacardioprotectiongliamicroscopynexus glia

Identifiers

PMID42296972
PMCPMC13360737

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.