Observational studyObesity (Silver Spring, Md.)2026
Six- and Twelve-Month Changes in Body Composition and 24-h Energy Expenditure After a Very Low-Calorie Ketogenic Diet.
Observational study in Obesity (Silver Spring, Md.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07418281 (Long Term Effect of VLCKD on Body Composition and 24-hour Energy Metabolism), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Long Term Effect of VLCKD on Body Composition and 24-hour Energy Metabolism
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
objectiveThis study assessed changes in body composition and 24-h energy metabolism at 6 and 12 months after initiation of a 1-month very low-calorie ketogenic diet (VLCKD) in women with obesity.
methodsSeventeen women with obesity who completed a 1-month VLCKD underwent a 4-week transition phase with carbohydrate reintroduction, followed by a hypocaloric balanced diet. Assessments of body composition by dual-energy X-ray absorptiometry (DXA) and 24-h energy expenditure (24hEE) by a whole-room indirect calorimeter were performed.
resultsFollowing the initial 7% weight loss, body weight further decreased at 6 months (-3.9%, p < 0.05), primarily driven by a significant decrease in fat mass (-10%, p < 0.05). From 6 to 12 months, three participants continued to lose weight, whereas most remained stable or partially regained. Lean soft tissue, decreased during the VLCKD phase, remained stable throughout follow-up. Both 24hEE and 24-h sleeping metabolic rate exhibited a progressive trend toward increase. Minute-by-minute 24hEE trajectories revealed a significant increase in metabolic rate from 1 to 6 months (p < 0.001). The metabolic adaptation observed after 1 month of VLCKD was no longer detectable at either 6 or 12 months.
conclusionsThese findings provide novel insight into the physiological adaptations following VLCKD, supporting its role in supervised weight loss programs for selected patients.
trial registrationClinicalTrials.gov identifier: NCT07418281.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.