Evidence map›Paper›PMID 42297616›Full record

ArticleHua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology2026

[Expression of Rho-related BTB domain-containing protein 1 in tongue squamous cell carcinoma and its effect on cell proliferation, invasion, and migration].

Yu Shao, Yingju Wang, Wenyuan Yu, Yong Xu, Jin Xu, Xia Wang, Zhenggang Chen

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yu ShaoSchool of Stomatology, Shandong Second Medical University, Weifang 261053, China.
Yingju WangDept. of Stomatology, Qing-dao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao 266071, China.
Wenyuan YuThe Affiliated Yantai Stomatological Hospital, Binzhou Medical University, Yantai 264000, China.
Yong XuSchool of Stomatology, Binzhou Medical University, Yantai 264003, China.
Jin XuSchool of Stomatology, Binzhou Medical University, Yantai 264003, China.
Xia WangThe Affiliated Yantai Stomatological Hospital, Binzhou Medical University, Yantai 264000, China.
Zhenggang ChenThe Affiliated Yantai Stomatological Hospital, Binzhou Medical University, Yantai 264000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study explored the expression of Rho-related BTB domain-containing protein 1 (Rho-BTB1) in tongue squamous cell carcinoma (TSCC) cells; its effects on TSCC cell proliferation, invasion, and migration; and the underlying molecular mechanisms.

methodsRhoBTB1 expression in TSCC was analyzed by querying a bioinformatics online database. Forty-five cases of primary TSCC lesions resected during oral and maxillofacial surgery from December 2024 to August 2025 were selected. Immunohistochemistry and Western blot were used to detect RhoBTB1 expression in TSCC tissues and adjacent tissues. Two kinds of TSCC cell lines, CAL-27 and SCC-25, were selected for

resultsRhoBTB1 expression in TSCC tissues was significantly lower than that in adjacent tissues (

conclusionsRhoBTB1 is lowly expressed in TSCC and may inhibit its malignant phenotype by negatively regulating the ROCK1/PTEN/AKT pathway, suggesting its potential as an oncogene and therapeutic target.

Indexed as

Carcinoma, Squamous Cellrho GTP-Binding ProteinsTongue NeoplasmsCell Line, TumorCell MovementCell ProliferationFemaleHumansNeoplasm InvasivenessProto-Oncogene Proteins c-aktPTEN Phosphohydrolaserho-Associated KinasesProto-Oncogene Proteins c-aktPTEN PhosphohydrolasePTEN protein, humanrho-Associated Kinasesrho GTP-Binding ProteinsinvasionmigrationproliferationPTEN/AKT signaling pathwayRho-related BTB domain-containing protein 1Rho-related protein kinase 1tongue squamous cell carcinoma

Identifiers

PMID42297616
PMCPMC13268861

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.