ArticleScientific reports2026
Leptin-induced autophagy regulates the immunomodulatory potential of adipose-derived mesenchymal stem cells through down regulating the expression of TSG-6.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Adipose-derived mesenchymal stem cells (ADMSCs) possess modulatory functions in adipose tissue, which could help combat the development of obesity. It has been reported that the functions of ADMSCs are impaired by obese microenvironment. However, the mechanisms are not clearly understood. The study investigates the role of leptin on immunoinhibitory functions of ADMSCs in obesity, and primarily explored its possible mechanisms. ADMSCs were isolated and identified by morphological observation, flow cytometry and differentiation potential. The lipopolysaccharides (LPS)-stimulated macrophages were co-cultured with ADMSCs pretreated with or without leptin. The expression of macrophage-associated markers was detected by flow cytometry. The secretion of inflammatory cytokines was evaluated by ELISA. Autophagy and MAPK signaling related proteins were detected by western blotting. Furthermore, the expression of tumor necrosis factor-alpha-stimulated protein 6 (TSG-6) was detected by western blotting, qRT-PCR, and ELISA. ADMSCs belonged to CD73
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