ArticleNeurology and therapy2026
Digital Motor Outcomes Capture Upper Limb and Mild Stage Impairment in Hereditary Spastic Paraplegia.
Article in Neurology and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionDigital motor outcomes may surpass the sensitivity of clinician-reported outcomes in hereditary spastic paraplegia (HSP), particularly in cases of mild upper limb impairment and early disease stages. We thus validated a trial-ready quantitative motor (Q-Motor) assessment of rapid alternating limb movement tasks against clinician-reported, patient-focused, and performance outcomes in HSP.
methodsExploratory single-center cross-sectional assessment in 41 patients with different HSP genotypes (age: 48 ± 14 years), with speeded foot tapping, diadochokinesia, and finger tapping measured by a high-resolution force transducer. Validation comprised discrimination from 48 age- and sex-matched controls; correlations to the Spastic Paraplegia Rating Scale (SPRS; mean: 18.6 ± 9.1), Friedreich Ataxia Rating Scale- Activities of Daily Living (FARS-ADL), and Nine-Hole Peg Test (9HPT); and stratification by functional stage (FARS stage: mild/moderate/severe = ambulatory/walking aid/wheelchair).
resultsFoot tapping best discriminated patients with HSP from controls (e.g., frequency: area under the curve [AUC] = 0.94-0.96), and particularly captured HSP severity and functional impairment by measures of foot elevation and cumulative tap force (across all measures: |rho
conclusionQ-Motor captures motor impairment in HSP, even in the upper limbs and mild disease stages, and should be further evaluated as a possible trial outcome by longitudinal validation in genotypically stratified cohorts and mapping to patient experience.
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