Trial reportEuropean journal of clinical nutrition2026
Effect of combined probiotic and iron-folic acid supplementation on iron status and gut inflammation markers: a randomized controlled trial among anaemic children.
Trial report in European journal of clinical nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
7 authors.
Funding
Abstract
backgroundIron supplementation can negatively affect gut health, while probiotics may improve intestinal iron absorption and gut health. Therefore, combined supplementation of iron and probiotics could be beneficial.
methodsA placebo-controlled randomised controlled trial was conducted among 248 anaemic (Hb 7-10.9 g/dL) children under 5 years of age. Participants were randomly assigned to receive intervention either with Iron-Folic acid (IFA) syrup (3 mg elemental iron/kg body weight/day) along with probiotic (Lactobacillus plantarum UBLP40, 10
resultsAt the end of the intervention, mean haemoglobin significantly increased from baseline in both groups (intervention: n = 79, 1.96 ± 1.35 g/dL vs. control: n = 86, 1.91 ± 1.36 g/dL, p < 0.001, paired t-test for within-group comparisons). The prevalence of anaemia reduced by (77.4% vs. 79.8%), iron deficiency (98.0% vs. 94.8%) and iron deficiency anaemia (100%) in intervention and control groups, respectively. No significant between-group differences were observed in haemoglobin, anaemia prevalence, iron status, morbidity, or gut health. In multiple regression analysis, rise in haemoglobin was associated with baseline haemoglobin, but not with probiotic use.
conclusionsProbiotic supplementation alongside IFA provided no additional benefits on iron status, adverse effects or gut health markers among anaemic Indian children. The absence of a placebo-only group, due to ethical considerations, limited the ability to isolate the net effect of the intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.