Evidence map›Paper›PMID 42298137›Full record

SynthesisObesity surgery2026

The Impact of Metabolic Bariatric Surgery on the Incidence of Breast Cancer in Patients with Obesity: A Systematic Review and Meta-Analysis.

Ragad Jalmood, Walaa Alsafari, Hassan Al-Asiry, Mohammed Almutairi, Abdullah Alzahrani, Saad Alahmari, Sara Alahmadi, Ghada Alalawi, Mohammed Almuhaisen, Atheer Albalawi and 3 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Obesity surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ragad JalmoodKing Abdulaziz University, Jeddah, Saudi Arabia. ragadjalmood@gmail.com.
Walaa AlsafariDar Al Uloom University, Riyadh, Saudi Arabia.
Hassan Al-AsiryKing Abdulaziz University, Jeddah, Saudi Arabia.
Mohammed AlmutairiArmed Forces Hospital, Qassim, Saudi Arabia.
Abdullah AlzahraniKing Abdulaziz University, Jeddah, Saudi Arabia.
Saad AlahmariKing Saud University, Riyadh, Saudi Arabia.
Sara AlahmadiTaibah University, Medina, Saudi Arabia.
Ghada AlalawiIbn Sina National College for Medical Studies, Jeddah, Saudi Arabia.
Mohammed AlmuhaisenKing Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Atheer AlbalawiTaibah University, Medina, Saudi Arabia.
Suzan AlajlanImam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia.
Noor AlsannaaBatterjee Medical College, Dammam, Saudi Arabia.
Ameen AlshehriPrince Mohammed bin Abdulaziz Hospital, Riyadh, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionObesity is widely recognized as an important risk factor for breast cancer, largely due to its effects on hormonal regulation, chronic low-grade inflammation, and metabolic dysfunction. Metabolic bariatric surgery (MBS) produces long-term weight reduction and improves metabolic profiles, which may influence the development of obesity-related cancers. This systematic review and meta-analysis aimed to examine the relationship between bariatric surgery and breast cancer incidence in adult women with obesity.

methodsThis review followed the PRISMA reporting standards and was registered in PROSPERO. A comprehensive search of PubMed, Google Scholar, Cochrane Library, and Web of Science was performed to identify studies comparing adult underwent metabolic bariatric surgery (MBS) with those managed without surgery. Breast cancer incidence was defined as the primary outcome. Study screening, data extraction, and quality appraisal were carried out independently by multiple reviewers. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using a random-effects model.

resultsEight eligible studies involving 793,197 participants were included in the analysis. Among them, 140,880 women had undergone bariatric surgery, while 652,317 received non-surgical management. Women who underwent metabolic bariatric surgery demonstrated a significantly lower incidence of breast cancer compared with non-surgical controls (pooled HR 0.61; 95% CI 0.46-0.80). This risk reduction was observed in both premenopausal and postmenopausal populations.

conclusionAmong women with obesity, metabolic bariatric surgery is associated with a substantially reduced risk of developing breast cancer. While these findings suggest a potential protective effect, further large- scale prospective studies are necessary to clarify causality and identify patients who may benefit most from surgical intervention.

Indexed as

Bariatric SurgeryBreast NeoplasmsObesityObesity, MorbidFemaleHumansIncidenceRisk FactorsBreast cancerCancer preventionMetabolic bariatric surgeryObesityWomen’s health

Identifiers

PMID42298137

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.