Evidence map›Paper›PMID 42298249›Full record

ReviewBioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy2026

Monoclonal Antibodies Targeting Bacterial Infections: A Broad Review of the Field.

Matthew J Slarve, Christine Tkaczyk, Michael P Doyle, Timothy J Break, Alexander B Smith, Galit Alter, Brian Luna, Brad Spellberg, Antonio DiGiandomenico

Abstract readReview
In one paragraph

Review in BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Matthew J SlarveImmunology and Immune Therapeutics Department, University of Southern California Keck School of Medicine, 1441 Eastlake Ave, NTT 6419, Los Angeles, CCA 90033A, USA. matt.slarve@gmail.com.ORCID http://orcid.org/0000-0003-1399-9813
Christine TkaczykEarly Infectious Disease, Biopharmaceuticals Business Unit, AstraZeneca, One MedImmune Way, Gaithersburg, MD 20878, USA.
Michael P DoyleEarly Infectious Disease, Biopharmaceuticals Business Unit, AstraZeneca, One MedImmune Way, Gaithersburg, MD 20878, USA.
Timothy J BreakEarly Infectious Disease, Biopharmaceuticals Business Unit, AstraZeneca, One MedImmune Way, Gaithersburg, MD 20878, USA.
Alexander B SmithEarly Infectious Disease, Biopharmaceuticals Business Unit, AstraZeneca, One MedImmune Way, Gaithersburg, MD 20878, USA.
Galit AlterEarly Infectious Disease, Biopharmaceuticals Business Unit, AstraZeneca, One MedImmune Way, Gaithersburg, MD 20878, USA.
Brian LunaImmunology and Immune Therapeutics Department, University of Southern California Keck School of Medicine, 1441 Eastlake Ave, NTT 6419, Los Angeles, CCA 90033A, USA.
Brad SpellbergLos Angeles General Medical Center, Los Angeles, CA, USA.
Antonio DiGiandomenicoEarly Infectious Disease, Biopharmaceuticals Business Unit, AstraZeneca, One MedImmune Way, Gaithersburg, MD 20878, USA. antonio.digiandomenico@astrazeneca.com.

Funding

MAb Passive Vaccination against Acinetobacter baumanniiR01AI130060 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRAD J SPELLBERG · 2017 to 2026
$6.7M
NIAID NIH HHS R01 AI130060
6 · The paper itself

Abstract

The ever-increasing trend of antibiotic resistance necessitates new therapeutic strategies for fighting infection. Standing on decades of extensive research and development, monoclonal antibodies have great promise for treating antibiotic-resistant bacterial infections. In this comprehensive review of the field, we summarize the rapidly emerging field of monoclonal therapeutics that offer alternative approaches to target bacterial pathogens that pose critical concern to human health. Organizing the findings by species and by molecular target, we discuss antibodies that have demonstrated therapeutic potential as well as those that did not provide efficacy, highlighting new insights for the design and discovery of highly effective therapeutics for the future. Furthermore, we discuss the latest advances in molecular biology that have revolutionized the implementation, efficacy, and utility of monoclonal antibodies as therapeutics, and that continues to drive what will be an exciting era for antibacterial monoclonal antibodies.

Indexed as

Anti-Bacterial AgentsAntibodies, MonoclonalBacterial InfectionsAnimalsBacteriaDrug Resistance, BacterialHumansAnti-Bacterial AgentsAntibodies, Monoclonal

Identifiers

PMID42298249
PMCPMC13337890

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.