Evidence map›Paper›PMID 42298270›Full record

ArticleCardiovascular intervention and therapeutics2026

Longitudinal Trends and Outcomes in Transcatheter Aortic Valve Implantation: a report from the SwissTAVI Registry.

Thorald Stolte, Jakob Johannes Reichl, David Tueller, Felix Goetzinger, Max Wagener, Stefan Stortecky, Raban Jeger, Oliver Reuthebuch, Stefan Toggweiler, Enrico Ferrari and 10 more

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Article in Cardiovascular intervention and therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Thorald Stolte *Department of Cardiology, Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, 4, CH-4031 , Basel, Switzerland.
Jakob Johannes Reichl *Department of Cardiology, Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, 4, CH-4031 , Basel, Switzerland.
David TuellerDepartment of Cardiology, Triemli Hospital Zurich, Zurich, Switzerland.
Felix GoetzingerDepartment of Cardiology, Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, 4, CH-4031 , Basel, Switzerland.
Max WagenerDepartment of Cardiology, Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, 4, CH-4031 , Basel, Switzerland.
Stefan StorteckyDepartment of Cardiology, Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland.
Raban JegerDepartment of Cardiology, Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, 4, CH-4031 , Basel, Switzerland.
Oliver ReuthebuchDepartment of Cardiac Surgery, University Hospital Basel, University of Basel, Basel, Switzerland.
Stefan ToggweilerDepartment of Cardiology, Heart Center, Cantonal Hospital Lucerne, Lucerne, Switzerland.
Enrico FerrariDepartment of Cardiovascular Surgery, Cardiocentro Ticino Institute, Lugano, Switzerland.
Peter WenaweserHeart Clinic Hirslanden, Hirslanden Clinic Zurich, Zurich, Switzerland.
Fabian NietlispachCardiovascular Center Zurich, Hirslanden Klinik im Park, Zurich, Switzerland.
Christoph HuberDivision of Cardiology and Cardiovascular Surgery, University Hospital, Geneva, Switzerland.
Marco RoffiDivision of Cardiology and Cardiovascular Surgery, University Hospital, Geneva, Switzerland.
Dik HegDepartment of Clinical Research, University of Bern, Bern, Switzerland.
David MeierDivision of Cardiology, University Hospital, Lausanne, Switzerland.
Stephan WindeckerDepartment of Cardiology, Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland.
Felix MahfoudDepartment of Cardiology, Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, 4, CH-4031 , Basel, Switzerland.
Stephane NobleDivision of Cardiology and Cardiovascular Surgery, University Hospital, Geneva, Switzerland.
Thomas NestelbergerDepartment of Cardiology, Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, 4, CH-4031 , Basel, Switzerland. thomas.nestelberger@usb.ch.ORCID http://orcid.org/0000-0003-2173-5738

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The progressive expansion of indications for Transcatheter Aortic Valve Implantation (TAVI) towards lower-risk and younger populations has raised concerns about potential outcome attenuation with increasing procedural volumes. Real-world evidence addressing this concern is limited. To assess temporal trends in patient characteristics and procedural outcomes of TAVI in a large nationwide cohort. The Swiss TAVI Registry prospectively enrolled consecutive patients undergoing TAVI in Switzerland. Baseline characteristics, procedural complications and outcomes were compared across three periods: 2011-2015, 2016-2020 and 2021-2024. The primary endpoint was major adverse cardiovascular events (MACE: all-cause mortality, non-fatal myocardial infarction, and non-fatal stroke) at one year. The secondary endpoint was 30-day MACE. Among 19'452 patients, TAVI volume increased 27% annually. Patient age (82 years) and comorbidity burden remained stable, while the proportion of women increased (51% to 58%) and the median STS score decreased (4.5% to 3.3%). Considering the expansion to lower-risk patients, 1-year MACE declined significantly from 16% to 14% to 9.1% across periods (adjusted HR 0.69, 95% CI 0.62-0.78, p<0.001). Similarly, 30-day MACE decreased from 6.9% to 5.2% to 4.0% (adjusted HR 0.66, 95%CI 0.55-0.78, p<0.001). Procedural mortality declined from 2.9% to 1.2%, periprocedural myocardial infarction from 0.4% to 0.2% and stroke from 3.2% to 2.0% (all p<0.001).Risk-adjusted TAVI outcomes improved continuously despite a significant volume increase, with improvements exceeding those expected from lower-risk patients risk profiles alone.

Indexed as

Aortic Valve StenosisTranscatheter Aortic Valve ReplacementAgedAged, 80 and overFemaleHumansMalePostoperative ComplicationsProspective StudiesRegistriesRisk FactorsStrokeSwitzerlandTreatment OutcomeAortic stenosisAortic valveOutcomesTAVI

Identifiers

PMID42298270

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.