Evidence map›Paper›PMID 42298423›Full record

SynthesisBMC cardiovascular disorders2026

Intravascular imaging-guided versus angiography-guided percutaneous coronary intervention in multivessel coronary artery disease: a systematic review, meta-analysis, and trial sequential analysis of randomized controlled trials.

Ahmed Adel Mohamed, Asmaa Magdy Elhefnawy, Abdalrahman Salah Shehata, Sara Khalid, Abdelrahman Mostafa, Abdullah Ali, Baher Ibrahim, Tasneem Zanati Saeed, Mohammed Dibas

Abstract readNetwork Meta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC cardiovascular disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ahmed Adel MohamedFaculty of Medicine, Zagazig University, Zagazig, Egypt.
Asmaa Magdy ElhefnawyFaculty of Medicine, Zagazig University, Zagazig, Egypt.
Abdalrahman Salah ShehataFaculty of Medicine, Qena University, Qena, Egypt.
Sara KhalidFaculty of Medicine, Helwan University, Cairo, Egypt.
Abdelrahman MostafaFaculty of Medicine, Alexandria University, Alexandria, Egypt.
Abdullah AliFaculty of Medicine, Faqous Branch, Zagazig University, Zagazig, Egypt.
Baher IbrahimFaculty of Medicine, Zagazig University, Zagazig, Egypt.
Tasneem Zanati SaeedFaculty of Medicine, Assiut University, Assiut, Egypt.
Mohammed DibasDepartment of Medicine, Faculty of Medicine and Health Sciences, An-Najah National University, PO. Box 7, Nablus, Palestine. mohd.dibas@gmail.com.ORCID https://orcid.org/0009-0000-7324-264X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPercutaneous coronary intervention (PCI) in patients with multivessel coronary artery disease is associated with increased anatomical complexity and adverse cardiovascular outcomes. Conventional angiography provides limited assessment of vessel structure and plaque characteristics, whereas intravascular imaging with intravascular ultrasound (IVUS) or optical coherence tomography (OCT) may improve procedural guidance. However, the clinical impact of imaging-guided PCI in this population remains uncertain.

methodsWe conducted a systematic review and meta-analysis of randomized controlled trials comparing intravascular imaging-guided versus angiography-guided PCI in patients with multivessel coronary artery disease regarding major adverse cardiovascular events (MACE). Major databases were searched through December 2025. Outcomes were pooled as risk ratios (RRs) with 95% confidence intervals (CIs) using random-effects models. Trial sequential analysis (TSA) and an exploratory network meta-analysis (NMA) were performed.

resultsFive randomized trials, including 3,023 patients, were analyzed. Imaging-guided PCI was associated with a significant reduction in MACE compared with angiography-guided PCI (RR 0.58, 95% CI 0.46 to 0.74; p < 0.0001; I

conclusionIntravascular imaging-guided PCI is associated with a reduction in MACE in patients with multivessel coronary artery disease. These findings support the clinical value of intravascular imaging in this population, with similar effects observed across imaging modalities.

Indexed as

Coronary AngiographyCoronary Artery DiseasePercutaneous Coronary InterventionRadiography, InterventionalTomography, Optical CoherenceUltrasonography, InterventionalAgedFemaleHumansMaleMiddle AgedPredictive Value of TestsRandomized Controlled Trials as TopicRisk AssessmentRisk FactorsTreatment OutcomeCoronary artery diseaseIntravascular imagingIntravascular ultrasoundMajor adverse cardiovascular eventsMultivessel coronary artery diseaseOptical coherence tomographyPercutaneous coronary intervention

Identifiers

PMID42298423
PMCPMC13495394

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.