Evidence map›Paper›PMID 42298556›Full record

ReviewCell communication and signaling : CCS2026

Neurotransmitters in cancer: how receptor signaling and posttranslational modifications modulate tumor progression and offer new therapeutic targets.

Xuanyin Ding, Hele Liu, Weiran Zhang, Jie Shen, Yuting Zhang, Danni Zhao, Minjie Guo, Xiao Yuan, Xu Wang, Dan Feng

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell communication and signaling : CCS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xuanyin Ding *Department of Thoracic Oncology, Cancer Institute of Jiangsu University, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Hele Liu *Department of Thoracic Oncology, Cancer Institute of Jiangsu University, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Weiran ZhangDepartment of Thoracic Oncology, Cancer Institute of Jiangsu University, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Jie ShenDepartment of Thoracic Oncology, Cancer Institute of Jiangsu University, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Yuting ZhangDepartment of Thoracic Oncology, Cancer Institute of Jiangsu University, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Danni ZhaoDepartment of Thoracic Oncology, Cancer Institute of Jiangsu University, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Minjie GuoDepartment of Thoracic Oncology, Cancer Institute of Jiangsu University, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Xiao YuanInstitute of Oncology, Affiliated Hospital of Jiangsu University, Zhenjiang, China.
Xu WangDepartment of Thoracic Oncology, Cancer Institute of Jiangsu University, Affiliated Hospital of Jiangsu University, Zhenjiang, China. jsdxwx@126.com.
Dan FengDepartment of Pharmacy, Affiliated Hospital of Jiangsu University, Zhenjiang, China. dandanfung@163.com.

Funding

Jinshan Talents of High-level Talents Project in Medical Field (full-time doctor) No. JSYC2024-002National Natural Science Foundation of China 32170910Natural Science Foundation of Jiangsu Province BK20250130
6 · The paper itself

Abstract

Recent studies highlight the multifaceted roles of neurotransmitters in tumor immunomodulation, offering novel avenues for increasing therapeutic efficacy. These signaling molecules are classified into cholinergic agents, monoamines, amino acids, and peptides and regulate tumorigenesis, metastasis, and immune evasion via autocrine/paracrine pathways and receptor-mediated interactions. Notably, neurotransmitters influence tumor cell proliferation, apoptosis, and immune cell activity by modulating intracellular signaling cascades through posttranslational modifications (serotonylation and dopaminylation). Emerging evidence highlights their dual roles: serotonin enhances glycolysis in CD8

Indexed as

Disease ProgressionMolecular Targeted TherapyNeoplasmsNeurotransmitter AgentsProtein Processing, Post-TranslationalSignal TransductionAnimalsHumansNeurotransmitter AgentsImmunotherapyNeuroimmune crosstalkNeurotransmittersPosttranslational modificationsReceptor signalingTumor microenvironment

Identifiers

PMID42298556
PMCPMC13501782

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.