ArticleRadiation oncology (London, England)2026
Predicting the region of tumor micro-infiltration in glioblastoma peritumoral edema using a multiparametric mri radiomics model.
Article in Radiation oncology (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo predict tumor micro-infiltration (TMI) within glioblastoma (GBM) peritumoral edema (PTE) using MRI for postoperative radiation planning.
methodsStudy cohort consisted of a training group (TG) with 50 GBM and 50 brain metastasis tumor cases, a validation group (VG) with 25 GBM and 19 meningioma cases, and an image-pathology point-to-point VG (IPVG) with 10 additional GBM cases. Besides univariate analysis of gray-level histogram parameters (GLHP) of peritumoral edema (PTE) from contrast-enhanced T1-weighted imaging (CE-T1WI), T2 fluid-attenuated inversion recovery (T2FLAIR), and apparent diffusion coefficient (ADC) maps, LASSO regression removed collinear parameters. Then, forward stepwise logistic regression, SVM, and random forest were used to build TMI prediction models in PTE, with efficiency evaluated via ROC curves. In the IPVG, the coincidence rate between Python-based TMI predictions and biopsy pathology results was calculated.
resultsUnivariate analysis in the TG revealed that GLHP differences between GBM and BM PTE belts were prominent within 3 cm of PTE. After removing collinear parameters, the ADC map or CE-T1WI-based prediction model outperformed the T2FLAIR-based one. The model with the 1-cm GBM PTE belt and 2-cm BM PTE belt pairing showed superior discrimination. Incorporating ADC and CE-T1WI parameters, the RF model with 6 parameters (Ratio-maxi-enhancedT1/mean-enhancedT1, Ratio-miniADC/meanADC, etc.) demonstrated the best discrimination than other models, with an ROC curve (AUC) of 0.836 in the TG and 0.844 in the VG. In the IPVG, the TMI prediction model had an overall accuracy of 81.25%.
conclusionThe multiparametric RF model preoperative MRI can predict the TMI within PTE of GBM.
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