ArticleJournal of the Endocrine Society2026
Relevance of the KATP channel function for the basal insulin hypersecretion of islets from female NZO mice.
Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Context: The polygenic New Zealand obese (NZO) mouse model displays the characteristics of early type 2 diabetes: fasting hyperglycemia, hyperinsulinemia, and insulin resistance. The expression of the ATP-sensitive potassium (KATP) channels in the β cells was reported to be reduced. Objective: To define at the cellular level the role of the KATP channel function for the altered insulin secretion of NZO mice. Methods: We measured the plasma membrane potential, KATP channel currents, cytosolic Ca Results: The potassium current of NZO β cells had half the extent of that of NMRI β cells and remained so in the presence of the KATP channel opener, diazoxide. The KATP channel blocker, tolbutamide, reduced the currents to the same low level. At low glucose and in the presence of diazoxide, the plasma membrane potential of NZO β cells was less polarized, and consequently, [Ca Conclusion: The higher insulin secretion at basal glucose, but not the lower stimulated secretion of NZO islets, is at least partly due to the reduced expression of the KATP channels.
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