ArticlePlant physiology2026
Fingers for signaling? A possible role of stromules in intracellular communication.
Article in Plant physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Plastid stromules are frequently observed under stress, yet their function remains enigmatic. In the current study, we tested 2 alternative hypotheses: stromules might channel metabolic flux from plastids to peroxisomes during jasmonate biosynthesis, or they might serve as conduits for plastid-nucleus retrograde signaling. We used Nicotiana tabacum BY-2 cells to investigate stromulation in nonphotosynthetic plastids. Fluorescent markers for stroma, plastid outer membrane, peroxisomes, and the 12-oxo-phytodienoic acid (OPDA) exporter were combined with confocal visualization and AI-based quantification of stromule frequency and length. Exogenous methyl jasmonate (MeJA) and salicylic acid (SA) each triggered a rapid (∼60 min) ∼3-fold increase in stromule frequency. This increase primarily resulted from more initiation events, rather than elongation. Disrupting microtubules with oryzalin stopped MeJA from causing stromule formation, while actin depolymerization had no effect. Inhibition of jasmonate biosynthesis with Phenidone prevented SA-triggered stromule formation. MeJA-induced expression of genes involved in jasmonate biosynthesis (AOC) and jasmonate responses (JAZ1 and JAZ3) was further amplified when stromule formation was suppressed by oryzalin, suggesting that stromules modulate jasmonate-dependent gene expression. The GFP-fusion of the OPDA exporter JASSY showed a significant preference for stromules, and over 80% of them associated with peroxisomes. Stromule frequency was highest during the cell-expansion phase. We discuss our findings in the context of a role for stromules in stress-dependent retrograde signaling from plastids to the nucleus.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.