ArticleInvestigative ophthalmology & visual science2026
Monitoring of Geographic Atrophy Progression in Age-Related Macular Degeneration Using Fluorescence Lifetime Imaging Ophthalmoscopy.
Article in Investigative ophthalmology & visual science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The purpose of this study was to examine fluorescence lifetime (FLT) changes within the border zone of geographic atrophy (GA) due to age-related macular degeneration (AMD) using fluorescence lifetime imaging ophthalmoscopy (FLIO). Methods: Patients with GA due to AMD were included. Fundus autofluorescence (FAF) intensity, spectral-domain optical coherence tomography (OCT), color fundus photography, and FLIO imaging were carried out at baseline and approximately 5 years of follow-up. GA progression was measured based on FAF images. FLT were measured at five different regions of interest: fovea, retina unaffected by GA, GA, and two areas directly next to the border zone of atrophy. Results: Thirty-two eyes of 17 patients (9 female patients, mean age = 77.4 years) were included. The GA area increased by an average of 1.21 mm2/year. At the GA border, FLT gradually decreased toward the unaffected retina at each visit and gradually increased in all zones over time. The FLT gradient at the border zone correlated significantly with the GA growth rate (P = 0.02, r2 = 0.17). Conclusions: Areas of GA showed significantly prolonged FLT compared to unaffected surrounding retinal tissue, confirming previous reports. The border zone FLT gradient was predictive of GA progression rate.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.