Evidence mapPaperPMID 42300675Full record

ArticleInvestigative ophthalmology & visual science2026

MMP9 Genotype and Systemic T-Cell Subsets Correlate With Structural and Functional Outcomes in Neovascular Age-Related Macular Degeneration.

Thomas L Martinez, Zeb R Zacharias, Kyungmoo Lee, Ian C Han, Chunhua Jiao, Bernardo B Bach, Benjamin Roos, Srinivas Chava, Mary M McCormick, Christine Sinkey and 17 more

Abstract read
In one paragraph

Article in Investigative ophthalmology & visual science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Thomas L MartinezDepartment of Ophthalmology and Visual Sciences, University of Iowa Health Care, Iowa City, Iowa, United States.
Zeb R ZachariasDepartment of Microbiology and Immunology, University of Iowa Health Care, Iowa City, Iowa, United States.
Kyungmoo LeeDepartment of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, United States.
Ian C HanDepartment of Ophthalmology and Visual Sciences, University of Iowa Health Care, Iowa City, Iowa, United States.
Chunhua JiaoDepartment of Ophthalmology and Visual Sciences, University of Iowa Health Care, Iowa City, Iowa, United States.
Bernardo B BachDepartment of Ophthalmology and Visual Sciences, University of Iowa Health Care, Iowa City, Iowa, United States.
Benjamin RoosDepartment of Ophthalmology and Visual Sciences, University of Iowa Health Care, Iowa City, Iowa, United States.
Srinivas ChavaDepartment of Ophthalmology and Visual Sciences, University of Iowa Health Care, Iowa City, Iowa, United States.
Mary M McCormickDepartment of Ophthalmology and Visual Sciences, University of Iowa Health Care, Iowa City, Iowa, United States.
Christine SinkeyDepartment of Ophthalmology and Visual Sciences, University of Iowa Health Care, Iowa City, Iowa, United States.
Amy P WuDepartment of Biostatistics, University of Iowa College of Public Health, Iowa City, Iowa, United States.
Chirantan MukhopadhyayDepartment of Ophthalmology and Visual Sciences, University of Iowa Health Care, Iowa City, Iowa, United States.
Razek G CoussaDepartment of Ophthalmology and Visual Sciences, University of Iowa Health Care, Iowa City, Iowa, United States.
Jonathan RussellDepartment of Ophthalmology and Visual Sciences, University of Iowa Health Care, Iowa City, Iowa, United States.
Elaine M BinkleyDepartment of Ophthalmology and Visual Sciences, University of Iowa Health Care, Iowa City, Iowa, United States.
H Culver BoldtDepartment of Ophthalmology and Visual Sciences, University of Iowa Health Care, Iowa City, Iowa, United States.
James C FolkDepartment of Ophthalmology and Visual Sciences, University of Iowa Health Care, Iowa City, Iowa, United States.
Stephen R RussellDepartment of Ophthalmology and Visual Sciences, University of Iowa Health Care, Iowa City, Iowa, United States.
Robert F MullinsDepartment of Ophthalmology and Visual Sciences, University of Iowa Health Care, Iowa City, Iowa, United States.
John H FingertDepartment of Ophthalmology and Visual Sciences, University of Iowa Health Care, Iowa City, Iowa, United States.
Kai WangDepartment of Biostatistics, University of Iowa College of Public Health, Iowa City, Iowa, United States.
Michael D AbramoffDepartment of Ophthalmology and Visual Sciences, University of Iowa Health Care, Iowa City, Iowa, United States.
Edwin M StoneDepartment of Ophthalmology and Visual Sciences, University of Iowa Health Care, Iowa City, Iowa, United States.
Todd E ScheetzDepartment of Ophthalmology and Visual Sciences, University of Iowa Health Care, Iowa City, Iowa, United States.
Jon C D HoutmanDepartment of Microbiology and Immunology, University of Iowa Health Care, Iowa City, Iowa, United States.
Milan SonkaDepartment of Electrical and Computer Engineering, University of Iowa, Iowa City, Iowa, United States.
Elliott H SohnDepartment of Ophthalmology and Visual Sciences, University of Iowa Health Care, Iowa City, Iowa, United States.

Funding

MMP-9 based immune-driven mechanisms of neovascular AMDR01EY035435 · UNIVERSITY OF IOWA · 2025 to 2025
$540k
NEI NIH HHS R01 EY035435
6 · The paper itself

Abstract

Purpose: Genetic studies implicate the matrix metalloproteinase-9 (MMP9) locus in neovascular age-related macular degeneration (nvAMD) risk but genotype-phenotype associations of MMP9 with nvAMD are lacking. This study aimed to investigate the influence of MMP9 genotype and T-cell subset frequency on structural and functional treatment outcomes in nvAMD. Methods: We reanalyzed single-cell RNA sequencing data and used ELISA and flow cytometry in THP-1-derived monocytes to measure immune cell expression of MMP9 within human choroids. In a clinical nvAMD cohort of 38 patients, we genotyped the nvAMD risk single nucleotide polymorphism (SNP; rs4810482) and quantified retinal fluid using deep-learning-based optical coherence tomography (OCT) image analysis. On a subset of nine patients, we performed high-dimensional immunophenotyping. Results: MMP9 is predominantly expressed in mature THP-1-derived dendritic-like cells (ELISA, P = 0.009; flow cytometry, P = 0.001). Patients with the TC genotype of MMP9 exhibited greater disease severity compared to CC or TT genotypes with a significantly higher total retinal fluid volume (P = 0.009). Immunophenotyping revealed that higher proportions of circulating CD8+ effector memory T cells re-expressing CD45RA (TEMRA) were associated with increased residual subretinal fluid (P = 0.03), indicating persistent disease activity. Conclusions: MMP9 genotype affects structural and functional outcomes in patients with nvAMD. Along with the observed systemic immune dysregulation, these findings support the role of a MMP9-dendritic-T-cell axis in nvAMD immunopathogenesis and highlight this as a potential therapeutic target.

Indexed as

Choroidal NeovascularizationMatrix Metalloproteinase 9Polymorphism, Single NucleotideT-Lymphocyte SubsetsWet Macular DegenerationAgedAged, 80 and overEnzyme-Linked Immunosorbent AssayFemaleFlow CytometryGenotypeHumansImmunophenotypingMaleSubretinal FluidTomography, Optical CoherenceMatrix Metalloproteinase 9MMP9 protein, human

Identifiers

PMID42300675
PMCPMC13281956

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.