ReviewMetabolic brain disease2026
Hippocampal cytopathology orchestrates post-septic cognitive dysfunction.
Review in Metabolic brain disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
Funding
Abstract
Cognitive dysfunction induced by sepsis is a common clinical disease. The hippocampus is one of the brain regions most vulnerable to sepsis. However, the correlations between sepsis-mediated neural cell types, pathological characteristics, and molecular mechanisms in hippocampal tissue and brain cognitive damage remain incompletely understood. This review summarizes: (1) the pathological features and mechanisms of blood-brain barrier disruption in sepsis; (2) the pathological effects of sepsis on different types of hippocampal neurons and the underlying molecular mechanisms; (3) the activation of peripheral inflammatory cells and central resident microglia and their roles in neuronal and oligodendrocyte death, as well as synaptic pruning, along with the associated mechanisms; and (4) the activation of sepsis-induced reactive astrocytes and their impact on cognitive function. Finally, this article analyzes potential therapeutic strategies for sepsis-associated brain cognitive dysfunction.
Indexed as
Identifiers
42301345What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.