Evidence map›Paper›PMID 42301433›Full record

ArticlePediatric nephrology (Berlin, Germany)2026

Early, frequent, yet reversible: acute kidney injury after hematopoietic stem cell transplantation in pediatric Fanconi anemia and long-term renal outcomes.

Fahimeh Askarian, Zahra Karimizadeh, Amirali Kalantari, Mahsa Mousakhan Bakhtiari, Atieh Karimzadeh, Mohammad Jahanpanah, Shirin Eshghi, Nyasha Sandaramu, Leila Jafari, Amir Ali Hamidieh and 3 more

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Article in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Fahimeh AskarianPediatric Chronic Kidney Disease Research Center, Gene, Cell & Tissue Research Institute, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Zahra KarimizadehPediatric Cell and Gene Therapy Research Center, Gene, Cell & Tissue Research Institute, Tehran University of Medical Science, Tehran, Iran.
Amirali KalantariPediatric Cell and Gene Therapy Research Center, Gene, Cell & Tissue Research Institute, Tehran University of Medical Science, Tehran, Iran.
Mahsa Mousakhan BakhtiariPediatric Cell and Gene Therapy Research Center, Gene, Cell & Tissue Research Institute, Tehran University of Medical Science, Tehran, Iran.
Atieh KarimzadehPediatric Cell and Gene Therapy Research Center, Gene, Cell & Tissue Research Institute, Tehran University of Medical Science, Tehran, Iran.
Mohammad JahanpanahPediatric Cell and Gene Therapy Research Center, Gene, Cell & Tissue Research Institute, Tehran University of Medical Science, Tehran, Iran.
Shirin EshghiPediatric Cell and Gene Therapy Research Center, Gene, Cell & Tissue Research Institute, Tehran University of Medical Science, Tehran, Iran.
Nyasha SandaramuSchool of Medicine, International Campus, Tehran University of Medical Sciences, Tehran, Iran.
Leila JafariPediatric Cell and Gene Therapy Research Center, Gene, Cell & Tissue Research Institute, Tehran University of Medical Science, Tehran, Iran.
Amir Ali HamidiehPediatric Cell and Gene Therapy Research Center, Gene, Cell & Tissue Research Institute, Tehran University of Medical Science, Tehran, Iran.
Mohammad Taha Salmanifard ArdestaniPediatric Cell and Gene Therapy Research Center, Gene, Cell & Tissue Research Institute, Tehran University of Medical Science, Tehran, Iran.
Maryam BehfarPediatric Cell and Gene Therapy Research Center, Gene, Cell & Tissue Research Institute, Tehran University of Medical Science, Tehran, Iran. behfarm@tums.ac.ir.
Farahnaz PashaDepartment of Internal Medicine, Nephrology Division, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. farahnazpasha@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute kidney injury (AKI) is an understudied complication in pediatric Fanconi anemia (FA) patients undergoing hematopoietic stem cell transplantation (HSCT). This study evaluates AKI incidence, risk factors, renal trajectories, and survival impact in pediatric FA patients receiving uniform non-TBI conditioning.

methodsThis retrospective cohort study enrolled 37 pediatric patients (< 18 years) with confirmed FA who underwent allogeneic HSCT between April 2017 and June 2023 at Children's Medical Center, Tehran. AKI was defined and staged using KDIGO serum creatinine criteria, and renal function was tracked via estimated glomerular filtration rate (eGFR; bedside Schwartz equation).

resultsAKI developed in 13 of 37 patients (35.1%), mostly stage 1 (53.8%), with 92.3% of cases occurring within the first three months post-transplantation. Older age at HSCT (p = 0.023) and higher admission eGFR (p = 0.010) were associated with increased AKI risk. While binary CAKUT presence did not significantly correlate with AKI, subgroup analysis revealed single kidney or severe renal malrotation carried the highest risk. Longitudinal eGFR modelling showed a marked decline within one month post-HSCT and partial recovery by six months. Calcineurin inhibitor levels, conditioning intensity, GvHD grade, and CMV infection did not significantly correlate with AKI.

conclusionsAKI is common, mostly mild, and predominantly occurs early after transplantation, highlighting the need for risk-stratified renal monitoring, tailored immunosuppressive management, and long-term nephrological follow-up in FA patients surviving HSCT.

Indexed as

Acute Kidney InjuryFanconi AnemiaHematopoietic Stem Cell TransplantationAdolescentChildChild, PreschoolFemaleGlomerular Filtration RateHumansIncidenceInfantIranKidneyMaleRetrospective StudiesRisk FactorsAcute kidney injuryCongenital anomalies of the kidney and urinary tractFanconi anemiaGlomerular hyperfiltrationHematopoietic stem cell transplantationNon-TBI conditioningPediatric transplantationRenal function trajectories

Identifiers

PMID42301433

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.