Evidence map›Paper›PMID 42301492›Full record

ArticleEuropean journal of pediatrics2026

SREBP gene polymorphisms and ambulatory blood pressure parameters in Chinese adolescents: a cross-sectional study.

Jian Zhang, Julien S Baker, Yuan Zeng, Bin Mao, Yuxuan Jiang, Shengnan Li, Sha Xia, Jixin Zhang, Xiu-Qin Hong, Yi-de Yang

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Article in European journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

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10 authors.

Jian Zhang *Key Laboratory of Molecular Epidemiology of Hunan Province, School of Public Health, Hunan Normal University, Changsha, 410081, China.
Julien S Baker *Department of Sports and Health Sciences, Hong Kong Baptist University, Hong Kong, Hong Kong SAR, China.
Yuan Zeng *Changsha Municipal Center for Disease Control and Prevention, Changsha, China.
Bin MaoKey Laboratory of Molecular Epidemiology of Hunan Province, School of Public Health, Hunan Normal University, Changsha, 410081, China.
Yuxuan JiangKey Laboratory of Molecular Epidemiology of Hunan Province, School of Public Health, Hunan Normal University, Changsha, 410081, China.
Shengnan LiKey Laboratory of Molecular Epidemiology of Hunan Province, School of Public Health, Hunan Normal University, Changsha, 410081, China.
Sha XiaKey Laboratory of Molecular Epidemiology of Hunan Province, School of Public Health, Hunan Normal University, Changsha, 410081, China.
Jixin ZhangKey Laboratory of Molecular Epidemiology of Hunan Province, School of Public Health, Hunan Normal University, Changsha, 410081, China.
Xiu-Qin HongKey Laboratory of Molecular Epidemiology of Hunan Province, School of Public Health, Hunan Normal University, Changsha, 410081, China.
Yi-de YangKey Laboratory of Molecular Epidemiology of Hunan Province, School of Public Health, Hunan Normal University, Changsha, 410081, China. yangyide2007@126.com.

Funding

Hunan Province key research and development project 2023SK2059Hunan Provincial Natural Science Foundation of China 2025JJ50564Key Project of Developmental Biology and Breeding from Hunan Province 2022XKQ0205National College Student Innovation and Entrepreneurship Training Program S202410542075National Natural Science Foundation of China 81903336
6 · The paper itself

Abstract

The purpose of this study was to investigate the association between SREBP gene polymorphisms and ambulatory blood pressure phenotypes. In the present study, 514 college students from a university in China were recruited. Questionnaire surveys, physical examinations, ambulatory blood pressure monitoring, and blood samples were collected. The relationship between SREBP gene polymorphisms and ambulatory blood pressure parameters in college students was analyzed using a multivariable linear regression model. A total of 510 students with complete data were included in the final analysis. After adjustment for sex, age, weight status, ethnicity, monthly household income per capita, salt intake habits, fruit intake frequency, vegetable intake frequency, smoking, alcohol consumption, history of hypertension, and waist circumference, SREBP1/rs11868035 was associated with 24-h SBP levels in college students under the additive and recessive genetic models (additive: β = 1.39, P = 0.045; recessive: β = 1.75, P = 0.027), but results were not significant after Bonferroni correction (P > 0.0167). Under the recessive genetic model, SREBP1/rs11868035 was associated with daytime SBP levels (β = 1.97, P = 0.026), and SREBP2/rs2228314 was positively associated with daytime DBP levels in college students (β = 2.44, P = 0.033), but neither remained significant after Bonferroni correction (P > 0.0167).

conclusionSREBP gene polymorphisms exhibited suggestive associations with ambulatory blood pressure in Chinese adolescents. Although the associations were not significant after multiple testing correction, these findings suggest potential genetic influences on blood pressure regulation in youth and may inform future research on genetically informed approaches to hypertension prevention. WHAT IS KNOWN: • Accumulating evidence has demonstrated associations between SREBP gene polymorphisms and cardiometabolic phenotypes. • To date, no studies have investigated the association between SREBP gene polymorphisms and ambulatory blood pressure phenotypes. WHAT IS NEW: • In this exploratory analysis, we identified an association between the rs11868035 polymorphism in the SREBP1 gene and ambulatory blood pressure phenotypes, including 24-h and daytime systolic blood pressure, among Chinese adolescents. • The SREBP1/rs11868035 polymorphism appears to be associated with higher 24-h and daytime systolic blood pressure, whereas the SREBP2/rs2228314 polymorphism was positively associated with daytime diastolic blood pressure.

Indexed as

Blood PressureHypertensionPolymorphism, GeneticPolymorphism, Single NucleotideSterol Regulatory Element Binding Protein 1Sterol Regulatory Element Binding Protein 2AdolescentBlood Pressure Monitoring, AmbulatoryChinaCross-Sectional StudiesEast Asian PeopleFemaleHumansMalePhenotypeYoung AdultSREBF1 protein, humanSREBF2 protein, humanSterol Regulatory Element Binding Protein 1Sterol Regulatory Element Binding Protein 2Ambulatory blood pressureCollege studentSNPsSREBP

Identifiers

PMID42301492

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.