Evidence map›Paper›PMID 42301950›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2026

Biodegradable Core-Shell Magnetic Microrobots With High Cell Capacity for Precise Co-Delivery of Stem Cells and Bioactive Molecules.

Tan Tang, Han Gao, Lanyu Xing, Yongyan Hu, Yuqiong Wang, Hongxing Jia, Penghui Nie, Qiuting Zhang, Tujun Weng, Ye Xu

Abstract read
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tan TangSchool of Mechanical Engineering and Automation, Beihang University, Beijing, China.ORCID 0000-0001-9652-8659
Han GaoHangzhou International Innovation Institute, Beihang University, Hangzhou, China.
Lanyu XingSchool of Mechanical Engineering and Automation, Beihang University, Beijing, China.
Yongyan HuLaboratory Animal Center, Peking University First Hospital, Beijing, China.
Yuqiong WangBeijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China.
Hongxing JiaSchool of Mechanical Engineering and Automation, Beihang University, Beijing, China.
Penghui NieSenior Department of Orthopaedics, the Fourth Medical Centre, Chinese PLA General Hospital, Beijing, P. R. China.
Qiuting ZhangSchool of Mechanical Engineering and Automation, Beihang University, Beijing, China.
Tujun WengSenior Department of Orthopaedics, the Fourth Medical Centre, Chinese PLA General Hospital, Beijing, P. R. China.
Ye XuSchool of Mechanical Engineering and Automation, Beihang University, Beijing, China.ORCID 0000-0003-4322-244X

Funding

Fundamental Research Funds for the Central Universities YWF-22-K-101National Key Research and Development Program of China 2022YFB3804300National Natural Science Foundation of China NSFC 12072010National Natural Science Fund Program for Excellent Young Scientists (Overseas)
6 · The paper itself

Abstract

Cell-loaded magnetic microrobots hold promise for the targeted delivery of stem cells in tissue regeneration. However, achieving high cell-loading capacity alongside effective co-delivery of functional bioactive molecules remains a major challenge. Herein, we present a biodegradable magnetic microrobot featuring a core-shell architecture, designed to co-deliver stem cells and bioactive molecules. These microrobots are fabricated using a rotation-induced inertial focusing technique, which allows control over their size and morphology while significantly enhancing cell-loading capacity. The core, composed of a biodegradable magnetic microsphere (MMS), enables external magnetic navigation and sustained drug release, while the outer shell, formed by mesenchymal stem cells (MSCs), ensures therapeutic viability. The microrobots demonstrate robust magnetic maneuverability and spatial control even in complex and viscous environments. We validated their efficacy in both a rabbit in vivo model and an ex vivo human cartilage model, where co-delivery of MSCs and transforming growth factor-β1 (TGF-β) led to significant improvements in cartilage repair and functional tissue regeneration. This biodegradable core-shell microrobot offers a scalable, multifunctional platform for efficient co-delivery of cells and bioactive molecules, with strong potential for clinical translation in regenerative medicine.

Indexed as

Biocompatible MaterialsMagneticsMesenchymal Stem CellsRoboticsAnimalsHumansMicrospheresRabbitsBiocompatible Materialsbiomedical engineeringcartilageex vivomaterials sciencemesenchymal stem cellnanotechnologyregenerative medicinestem celltissue engineering

Identifiers

PMID42301950
PMCPMC13472267

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.