Evidence map›Paper›PMID 42303809›Full record

ReviewNature reviews. Cardiology2026

Role of systemic and epicardial adipose tissue in cardiometabolic disease.

Shaun Khanna, Gurkeerat Mann, Aditya Bhat, Andrew Lin, Anushka Patel, Stephen J Nicholls, Andrew Sindone, Damini Dey, Deepak L Bhatt, Clare Arnott and 2 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shaun KhannaCardiovascular Program, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.
Gurkeerat MannDepartment of Cardiology, Westmead and Blacktown Hospitals, Sydney, New South Wales, Australia.
Aditya BhatDepartment of Cardiology, Westmead and Blacktown Hospitals, Sydney, New South Wales, Australia.
Andrew LinImaging Research Laboratory, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Anushka PatelCardiovascular Program, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.
Stephen J NichollsVictorian Heart Hospital, Monash Health, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-9668-4368
Andrew SindoneDepartment of Cardiology, Concord Repatriation General Hospital, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0003-0075-805X
Damini DeyDepartment of Imaging, Cedars-Sinai Medical Centre, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-2236-6970
Deepak L BhattDepartment of Cardiology, Mount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-1278-6245
Clare ArnottCardiovascular Program, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.
Thomas H MarwickImaging Research Laboratory, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Nitesh NerlekarImaging Research Laboratory, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia. nitesh.nerlekar@monash.edu.ORCID http://orcid.org/0000-0002-3437-8648

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adipose tissue is increasingly recognized as an immunological and metabolic organ composed of multiple specialized depots that exert diverse effects on cardiometabolic health. Beyond total adiposity, the distribution and phenotypic state of regional adipose tissue depots, including visceral, subcutaneous and epicardial adipose tissue, contribute to shaping overall cardiovascular risk. These depots communicate with the vasculature and myocardium through endocrine, paracrine, vasocrine and neural pathways to mediate cardiovascular inflammation and remodelling. Advances in cardiac CT, MRI, dual-energy X-ray absorptiometry and artificial intelligence technologies in the past 5 years have resulted in highly reproducible measurements of adipose tissue volume, quality, density and radiomics. Emerging multiomics data now reveal how specific adipose tissue patterns correspond to pathways of inflammation and the development of cardiovascular disease. In this Review, we synthesize the current evidence across adipose depots, highlighting how their collective biology, more so than quantity alone, shapes cardiometabolic risk. Furthermore, we highlight emerging insights into adipose depot-specific biology, imaging phenotyping, ethnicity-related and sex-related differences, and potential therapeutic modulation. We also introduce the 'unified adipose tissue' model that conceptualizes all adipose tissue depots as components of a unified system, in which the biology rather than the total mass of adipose tissue drives cardiometabolic disease.

Identifiers

PMID42303809

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.