Evidence map›Paper›PMID 42303902›Full record

ArticleThe Journal of antibiotics2026

Catenulamide A, an acylated tripeptide containing 5-methoxy-L-kynurenine lactam from an actinomycete of the genus Catenuloplanes.

Most Lipy Khatun, Desy Wulan Triningsih, Naoya Oku, Toshihiko Nogawa, Natsuko Arai, Kazuki Takahashi, Nobuyasu Matsuura, Kaho Ito, Chisato Iwata, Shun Saito and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in The Journal of antibiotics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Most Lipy KhatunBiotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Imizu, Toyama, Japan.ORCID http://orcid.org/0009-0008-2796-974X
Desy Wulan TriningsihBiotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Imizu, Toyama, Japan.ORCID http://orcid.org/0000-0002-0934-8543
Naoya OkuBiotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Imizu, Toyama, Japan.ORCID http://orcid.org/0000-0002-2171-2168
Toshihiko NogawaMolecular Structure Characterization Unit, RIKEN Center for Sustainable Research Science, RIKEN, Wako, Saitama, Japan.ORCID http://orcid.org/0000-0003-1270-5270
Natsuko AraiGraduate School of Agricultural Science, Tohoku University, Sendai, Japan.
Kazuki TakahashiGraduate School of Agricultural Science, Tohoku University, Sendai, Japan.
Nobuyasu MatsuuraDepartment of Life Science, Faculty of Science, Okayama University of Science, Kita-ku, Okayama, Japan.
Kaho ItoDepartment of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Kohoku-ku, Yokohama, Kanagawa, Japan.
Chisato IwataDepartment of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Kohoku-ku, Yokohama, Kanagawa, Japan.
Shun SaitoDepartment of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Kohoku-ku, Yokohama, Kanagawa, Japan.ORCID http://orcid.org/0000-0001-9270-4272
Yasuhiro MeguroGraduate School of Agricultural Science, Tohoku University, Sendai, Japan.
Masaru EnomotoGraduate School of Agricultural Science, Tohoku University, Sendai, Japan.
Midori A AraiDepartment of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Kohoku-ku, Yokohama, Kanagawa, Japan.ORCID http://orcid.org/0000-0003-0254-9550
Yasuhiro IgarashiBiotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Imizu, Toyama, Japan. yas@pu-toyama.ac.jp.ORCID http://orcid.org/0000-0001-5114-1389

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel linear acylated tripeptide, catenulamide A (1), was isolated from a culture extract of Catenuloplanes sp. RD061694. Comprehensive spectroscopic analyses coupled with Marfey's analysis established that 1 comprised n-butyric acid, N-methyl-L-isoleucine, L-valine, and a lactamized new amino acid, 5-methoxy-L-kynurenine lactam. Compound 1 exhibited dual PPARα and PPARγ agonist activities in a luciferase reporter gene assay and anti-inflammatory potential by inhibiting nitric oxide production in lipopolysaccharide-stimulated murine macrophages with an IC

Indexed as

ActinomycetalesAnti-Inflammatory AgentsLactamsOligopeptidesAnimalsLactucaLipopolysaccharidesMacrophagesMiceNitric OxidePPAR alphaPPAR gammaSeedsAnti-Inflammatory AgentsLactamsLipopolysaccharidesNitric OxideOligopeptidesPPAR alphaPPAR gamma

Identifiers

PMID42303902

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.