Evidence map›Paper›PMID 42304030›Full record

ArticleScientific reports2026

Retrograde transduction of dopaminergic cells in substantia nigra of the rhesus monkey.

Anya S Plotnikova, Walter Lerchner, Alexander C Cummins, Gang Chen, Leonardo Salhani, Vincent D Costa, Bruno B Averbeck, Barry J Richmond, Zayd M Khaliq, Mark A G Eldridge

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Anya S PlotnikovaLaboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892, USA. anya.plotnikova@icahn.mssm.edu.
Walter LerchnerLaboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892, USA.
Alexander C CumminsLaboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892, USA.
Gang ChenScientific and Statistical Computing Core, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892, USA.
Leonardo SalhaniLaboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892, USA.
Vincent D CostaLaboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892, USA.
Bruno B AverbeckLaboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892, USA.
Barry J RichmondLaboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892, USA.
Zayd M KhaliqCellular Neurophysiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA.
Mark A G EldridgeLaboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, 20892, USA. mark.eldridge@newcastle.ac.uk.

Funding

NEURAL MECHANISMS OF MOTIVATION AND REWARDZ01MH002619 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI RICHMOND, BARRY J · 1992 to 2008
$2.7M
Biotechnology and Biological Sciences Research Council 27307Intramural NIH HHS Z01 MH002619Intramural Research Program MH002619-28Intramural Research Program NS003135Michael J. Fox Foundation for Parkinson's Research Aligning Science Across Parkinson's (ASAP) - 020529
6 · The paper itself

Abstract

Recent advances in molecular tools have changed how researchers approach selective neural modulation, especially in rodent models where germline modifications and viral vector delivery are readily optimized. However, these tools have not advanced as rapidly for nonhuman primates, despite critical need for translational gene therapy models. A key barrier is targeting specific neuronal populations in the larger primate brain with cell-type and circuit specificity. Dopaminergic neurons pose a particular challenge due to their inaccessible ventral midbrain location, where local injection non-selectively targets all dopaminergic neurons. This work provides NHP researchers with a comparison of retrograde viral vectors, highlighting one which achieves efficient dopaminergic neuron transduction, establishing a foundation for combining vectors with cell-type-specific enhancers for basic and translational applications.

Indexed as

Dopaminergic NeuronsSubstantia NigraTransduction, GeneticAnimalsGenetic VectorsLentivirusMacaca mulattaDopamine cellsLentivirusRetrogradeRhesus macaqueStriatumSubstantia nigraTransduction

Identifiers

PMID42304030
PMCPMC13534416

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.