Evidence map›Paper›PMID 42304482›Full record

ArticleNutrition & metabolism2026

PDK4 drives time-dependent physical endurance impairment during acute hypoxia by disrupting carbohydrate metabolism.

Peng Wang, Yundong Xia, Min Zhou, Xin Rao, Shuping Mao, Hedong Lang, Long Yi, Mantian Mi

Abstract read
PubMed Full text at PMC Publisher
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Article in Nutrition & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Peng WangResearch Center for Nutrition and Food Safety, Chongqing Key Laboratory of Nutrition and Health, Chongqing Medical Nutrition Research Center, Institute of Military Preventive Medicine, Third Military Medical University, Chongqing, 400038, P.R. China.
Yundong XiaResearch Center for Nutrition and Food Safety, Chongqing Key Laboratory of Nutrition and Health, Chongqing Medical Nutrition Research Center, Institute of Military Preventive Medicine, Third Military Medical University, Chongqing, 400038, P.R. China.
Min ZhouResearch Center for Nutrition and Food Safety, Chongqing Key Laboratory of Nutrition and Health, Chongqing Medical Nutrition Research Center, Institute of Military Preventive Medicine, Third Military Medical University, Chongqing, 400038, P.R. China.
Xin RaoResearch Center for Nutrition and Food Safety, Chongqing Key Laboratory of Nutrition and Health, Chongqing Medical Nutrition Research Center, Institute of Military Preventive Medicine, Third Military Medical University, Chongqing, 400038, P.R. China.
Shuping MaoResearch Center for Nutrition and Food Safety, Chongqing Key Laboratory of Nutrition and Health, Chongqing Medical Nutrition Research Center, Institute of Military Preventive Medicine, Third Military Medical University, Chongqing, 400038, P.R. China.
Hedong LangResearch Center for Nutrition and Food Safety, Chongqing Key Laboratory of Nutrition and Health, Chongqing Medical Nutrition Research Center, Institute of Military Preventive Medicine, Third Military Medical University, Chongqing, 400038, P.R. China.
Long YiResearch Center for Nutrition and Food Safety, Chongqing Key Laboratory of Nutrition and Health, Chongqing Medical Nutrition Research Center, Institute of Military Preventive Medicine, Third Military Medical University, Chongqing, 400038, P.R. China. amu_yilong@tmmu.edu.cn.
Mantian MiResearch Center for Nutrition and Food Safety, Chongqing Key Laboratory of Nutrition and Health, Chongqing Medical Nutrition Research Center, Institute of Military Preventive Medicine, Third Military Medical University, Chongqing, 400038, P.R. China. mantian_mi@tmmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExposure to acute hypoxia severely impairs skeletal muscle function, but the temporal dynamics and underlying mechanisms remain unclear.

methodsMale C57BL/6 mice were exposed to normobaric hypoxia (FiO

resultsEndurance was most severely impaired after 12 h of hypoxic exposure and showed a trend toward recovery by 72 h, whereas muscle strength declined progressively. Hypoxia induced a metabolic reprogramming favoring oxidative phosphorylation, coupled with a marked upregulation of PDK4 at 12 h. This was associated with increased pyruvate dehydrogenase (PDH) phosphorylation, favoring the diversion of pyruvate away from oxidation and contributing to lactate accumulation. Both DCA treatment and AAV-mediated PDK4 knockdown improved endurance performance under hypoxic conditions.

conclusionThese findings suggest that acute hypoxia impairs endurance, in part through PDK4-mediated alterations in pyruvate metabolism, providing a mechanistic basis for optimizing nutritional and therapeutic strategies under hypoxic stress.

Indexed as

Dichloroacetic acidHypoxiaMuscle strengthPhysical endurancePyruvate dehydrogenase kinase 4

Identifiers

PMID42304482
PMCPMC13508394

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.