ArticleJournal of health, population, and nutrition2026
Blood urea nitrogen to serum albumin ratio, systemic inflammation response index and diabetic macrovascular complications in Chinese inpatients: a cross-sectional analysis.
Article in Journal of health, population, and nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06651983 (Association of Inflammatory Factors With Complications in the Diabetic Population), which is not on this map. Not yet cited in PubMed.
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The trial behind it
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Association of Inflammatory Factors With Complications in the Diabetic Population: a Cross-sectional Study
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10 authors.
Funding
Abstract
backgroundDiabetic patients often experience prolonged hyperglycemia, which leads to sustained harm and malfunction of various body organs. The blood urea nitrogen (BUN) to serum albumin ratio (BAR) and systemic inflammation response index (SIRI) have been proven to be reliable indicators. We aimed to investigate the association of BAR, SIRI and their combination with the risk of diabetic macrovascular diseases.
methodsA total of 2,911 participants from Nanfang Hospital diagnosed with type 2 diabetes mellitus (T2DM) were included. Restricted cubic spline (RCS) and logistic regression modelling were used to assess the relation between different values of BAR, SIRI and combined BAR-SIRI and the risk of diabetic macrovascular complications. Receiver operating curve (ROC) analysis was used to compare the predictive value of BAR, SIRI, and their combination for macrovascular outcomes.
resultsHigh value of BAR, SIRI and their combination were associated with increased risk of macrovascular complications (BAR: odds ratio [OR] = 1.45, 95% confidence interval [CI]: 1.18-1.78; SIRI: OR(95% CI) = 1.25(1.03,1.52); BAR-SIRI: OR(95%CI) = 1.51(1.21,1.88); all p < 0.05). ROC curve analysis demonstrated that combined BAR-SIRI has the best predictive value for risk of macrovascular outcomes (area under the ROC curve [AUC]: BAR-SIRI: 0.678 > SIRI: 0.674 > BAR: 0.673).
conclusionBAR, SIRI and their combination exhibit a notable positive correlation with the risk of diabetic macrovascular disease and may be independent predictors of macrovascular complications. CLINICAL
trial registrationClinicalTrials.gov, TRN: NCT06651983, Registration date: 19 May 2025.
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