ArticleThe Journal of international medical research2026
Nonlinear association of the non-high-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio with cognitive function in older Chinese adults: A prospective cohort study.
Article in The Journal of international medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
ObjectiveAlthough the non-high-density lipoprotein cholesterol-to-high-density lipoprotein cholesterol ratio (NHHR) has emerged as a novel indicator of lipid metabolism, its specific correlation with cognitive function remains unclear. This study aimed to comprehensively explore this association in an aging population.MethodsThis prospective cohort study comprised both cross-sectional (2015, n = 4605) and longitudinal (2018, n = 2362) analyses using data from the China Health and Retirement Longitudinal Study. Regression analysis was performed to assess the association of the NHHR with cognitive performance and cognitive impairment. Restricted cubic spline models explored potential nonlinear associations. A logistic regression model was employed in the longitudinal research to examine the correlation between baseline NHHR levels and cognitive impairment during follow-up.ResultsNHHR was positively correlated with episodic memory (regression coefficient = 0.23,
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