Evidence map›Paper›PMID 42304829›Full record

ArticleHIV medicine2026

Comparison of four frailty scores to predict adverse health events and mortality in people living with HIV aged 70 years and more (ANRS EP 66 SEPTAVIH study).

Clotilde Allavena, Diane Abulizi, Hubert Blain, Valérie Andriantsoanirina, Sophie Abgrall, Laurence Slama, Valérie Pourcher, Miresta Previlon, Marianne Canonico, Marcia Trumeau and 4 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in HIV medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Clotilde AllavenaInfectious Diseases Department INSERM CIC1413, Nantes University Hospital, Nantes, France.ORCID https://orcid.org/0000-0003-1010-1270
Diane AbuliziINSERM CESP U1018, Paris-Saclay University, UVSQ, Le Kremlin-Bicêtre, France.
Hubert BlainDepartment of Geriatrics, University of Montpellier, Montpellier, France.
Valérie AndriantsoanirinaINSERM CESP U1018, Paris-Saclay University, UVSQ, Le Kremlin-Bicêtre, France.
Sophie AbgrallINSERM CESP U1018, Paris-Saclay University, UVSQ, Le Kremlin-Bicêtre, France.ORCID https://orcid.org/0000-0002-7891-7594
Laurence SlamaInfectiology, Hôpital Hôtel Dieu AP-HP, Paris, France.ORCID https://orcid.org/0000-0002-9871-6036
Valérie PourcherDepartment of Infectious Diseases, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), AP-HP, Pitié-Salpêtrière Hospital, Sorbonne University, Paris, France.
Miresta PrevilonInfectious Diseases Department, Hôpital Saint Louis AP-HP, Paris, France.
Marianne CanonicoINSERM CESP U1018, Paris-Saclay University, UVSQ, Le Kremlin-Bicêtre, France.
Marcia TrumeauANRS MIE, Paris, France.
André CabieInfectious Diseases Department, Martinique University Hospital, INSERM CIC2504, Fort de France, PCCEI, Univ Montpellier, INSERM, Univ Antilles, Montpellier, France.
Fabrice BonnetInfectious Diseases Department, Bordeaux University Hospital, Bordeaux, France.ORCID https://orcid.org/0000-0001-5927-4178
Laurence MeyerINSERM CESP U1018, Paris-Saclay University, UVSQ, Le Kremlin-Bicêtre, France.
Alain MakinsonInfectious Diseases department, InsermU1175, Montpellier University Hospital, Montpellier, France.

Funding

ANRS MIEMSD Sharp and DohmeViiV Healthcare
6 · The paper itself

Abstract

introductionAs people living with HIV age, frailty has emerged as a determinant of adverse health outcomes. We evaluated four frailty assessment tools in their ability to predict adverse health outcomes and mortality in people living with HIV.

methodsWe enrolled 508 people living with HIV aged ≥70 years. At baseline, frailty was assessed using the Fried frailty phenotype, the FRAIL scale, the Study of Osteoporotic Fractures (SOF) score and the French Health Authority (HAS) questionnaire. The primary outcome was adverse health events (serious or recurrent falls, emergency department visits, unscheduled hospitalizations, nursing home admission or death) over 36 months. Log-binomial regression models estimated relative risks (RRs) for adverse outcomes in the 355 participants with a 36 months visit follow-up or death. Cox proportional hazards models assessed mortality in all enrolled people living with HIV.

resultsOver 36 months, 204 participants (40.2%) experienced our primary outcome, including 40 deaths. Frailty was associated with a higher risk of adverse outcomes with all tools: Fried phenotype [RR 1.41, 95% confidence interval (CI) 1.06-1.86], FRAIL scale (RR 1.88, 95% CI 1.54-2.29), SOF score (RR 1.45, 95% CI 1.05-2.00) and HAS questionnaire (RR 1.64, 95% CI 1.40-1.92). All tools were strongly associated with mortality, except the SOF score.

conclusionsIn people living with HIV aged ≥70 years, all four frailty tools predicted adverse health outcomes, whilst mortality was best predicted by the Fried phenotype, FRAIL scale and HAS questionnaire. Simple, questionnaire-based tools such as the FRAIL scale and the HAS questionnaire offer practical and effective frailty screening tools in routine HIV care for older adults.

Indexed as

FrailtyHIV InfectionsAgedAged, 80 and overFemaleFrail ElderlyGeriatric AssessmentHumansMaleSurveys and Questionnairesageing populationfrailtyHIV infectionmortalityscores

Identifiers

PMID42304829
PMCPMC13547428

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.