ReviewJournal of orthopaedic translation2026
Circadian rhythm: The hidden "puppet master" behind musculoskeletal disorders.
Review in Journal of orthopaedic translation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Circadian rhythm (CR), regulated by the central biological clock in the hypothalamus and synchronized with local clocks in peripheral tissues, orchestrates the physiology of localized tissues in response to the periodic rhythmic variations of the environment. Environmental cues and behavioral factors, such as light exposure, feeding, and exercise, can synchronize or desynchronize these rhythms, and abnormalities can lead to disruption of the human CR. Certain modern behaviors, such as traveling across time zones, shift work, and irregular eating patterns, disrupt the body's natural CR, thereby potentially contributing to the development of musculoskeletal disorders through multiple pathways. In this review, we summarize the role of CR in the physiology of the musculoskeletal system-encompassing bone, cartilage, tendons, and muscles-alongside the mechanisms by which CR disruption contributes to various musculoskeletal disorders. Additionally, we discuss interventions for treating musculoskeletal disorders based on CR, including resetting biological clocks or optimizing medication administration times.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.