ArticleArchives of medical science : AMS2026
The impact of diffuse large B-cell lymphoma-derived exosomes on macrophage polarisation and cytokine release.
Article in Archives of medical science : AMS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Levels of small extracellular vesicles in patients treated with hyperbaric oxygenation.Archives of medical science : AMS · 2024Article
- Changes in gene expression profiles and cytokine secretions in peripheral monocytes by treatment with small extracellular vesicles derived from a canine lymphoma cell line.The Journal of veterinary medical science · 2022Article
- Conditioned Media-Derived Tumor Extracellular Vesicles: Bridging Molecular Insights and Therapeutic Applications in Oncology.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The pro-tumoural role of M2 macrophages has been described in various cancers and is associated with poor clinical outcomes. Exosomes derived from cancers can shuttle information among tumour cells, immune cells, and the microenvironment, leading to microenvironment remodelling. The mechanism involved in exosomes influencing macrophages polarisation is still unclear. Material and methods: We established a macrophage model derived from THP-1 monocytes. To mimic the Results: DLBCL-derived exosomes had different effects on macrophages at different differentiation stages; these macrophages had different effects on drug-induced apoptosis of lymphoma cells in indirect co-culture. Moreover, NF-κB signalling molecules were involved in this process. Conclusions: The results indicate that DLBCL-derived exosomes can lead to more M2 phenotypes, promote tumour growth, and play a substantial role in tumour progression, invasion, and drug-resistance.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.